| The mechanical PR interval in fetuses of women with intrahepatic cholestasis of pregnancy. | |
| | |
MedLine Citation:
|
PMID: 20684945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The purpose of this study was to evaluate the fetal mechanical PR interval in intrahepatic cholestasis of pregnancy (ICP). STUDY DESIGN: Fetal echocardiography was performed for women with ICP and control subjects. Clinical characteristics, total bile acids, and liver profile tests were compared between groups. RESULTS: Fourteen women with ICP and 7 control subjects were enrolled. Total bile acids (28.3 vs 6.2 μmol/L; P < .001), aspartate aminotransferase (53 vs 23 IU/L; P = .002), alanine aminotransferase (63 vs 19 IU/L; P = .002), and the PR interval (124 vs 110 msec; P = .006) were significantly higher in fetuses with ICP than in control fetuses. On multivariable linear regression analysis, only the presence of ICP was associated significantly with an increase in the PR interval (95% confidence interval, 4-24 msec; P = .01). CONCLUSION: The fetal cardiac conduction system is altered in ICP. Further investigation is needed to determine whether fetal echocardiography can help to predict which fetuses are at risk for death that is associated with ICP. |
| | |
Authors:
|
Stacy L Strehlow; Bhuvan Pathak; Thomas M Goodwin; Belinda M Perez; Mahmood Ebrahimi; Richard H Lee |
Related Documents
:
|
19030215 - Albumin liver dialysis as pregnancy-saving procedure in cholestatic liver disease and i... 4053485 - Liver diseases in pregnancy. 3799155 - Maximal response to oxytocin of the isolated myometrium from pregnant patients with int... 1062535 - Middle-third facial osteotomies: their use in the correction of congenital dentofacial ... 1865405 - Wegener's granulomatosis complicated by pregnancy. a case report. 21392225 - Sildenafil citrate therapy for severe early-onset intrauterine growth restriction. |
Publication Detail:
|
Type: Journal Article Date: 2010-08-03 |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: 203 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-08 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
|
Languages: eng Pagination: 455.e1-5 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2010 Mosby, Inc. All rights reserved. |
Affiliation:
|
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, LAC+USC Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cholestasis, Intrahepatic / ultrasonography* Female Heart Conduction System / ultrasonography* Humans Linear Models Pregnancy Pregnancy Complications / ultrasonography* Ultrasonography, Prenatal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lipoxygenase and cyclooxygenase inhibitors reveal a complementary role of arachidonic acid derivativ...
Next Document: Venous Doppler studies in low-output and high-output hydrops fetalis.