Document Detail

The mechanical PR interval in fetuses of women with intrahepatic cholestasis of pregnancy.
MedLine Citation:
PMID:  20684945     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to evaluate the fetal mechanical PR interval in intrahepatic cholestasis of pregnancy (ICP).
STUDY DESIGN: Fetal echocardiography was performed for women with ICP and control subjects. Clinical characteristics, total bile acids, and liver profile tests were compared between groups.
RESULTS: Fourteen women with ICP and 7 control subjects were enrolled. Total bile acids (28.3 vs 6.2 μmol/L; P < .001), aspartate aminotransferase (53 vs 23 IU/L; P = .002), alanine aminotransferase (63 vs 19 IU/L; P = .002), and the PR interval (124 vs 110 msec; P = .006) were significantly higher in fetuses with ICP than in control fetuses. On multivariable linear regression analysis, only the presence of ICP was associated significantly with an increase in the PR interval (95% confidence interval, 4-24 msec; P = .01).
CONCLUSION: The fetal cardiac conduction system is altered in ICP. Further investigation is needed to determine whether fetal echocardiography can help to predict which fetuses are at risk for death that is associated with ICP.
Stacy L Strehlow; Bhuvan Pathak; Thomas M Goodwin; Belinda M Perez; Mahmood Ebrahimi; Richard H Lee
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Publication Detail:
Type:  Journal Article     Date:  2010-08-03
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  203     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-08     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  455.e1-5     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 Mosby, Inc. All rights reserved.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, LAC+USC Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
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MeSH Terms
Cholestasis, Intrahepatic / ultrasonography*
Heart Conduction System / ultrasonography*
Linear Models
Pregnancy Complications / ultrasonography*
Ultrasonography, Prenatal

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