Document Detail

The measurement of haemostatic factors in 16 European laboratories: quality assessment for the Multicentre ECAT Angina Pectoris Study. Report from the European Concerted Action on Thrombosis and Disabilities (ECAT).
MedLine Citation:
PMID:  2665175     Owner:  NLM     Status:  MEDLINE    
As part of a European multicentre prospective study involving the measurement of a number of haemostatic factors, a quality assessment (QA) scheme was organized. This paper describes the preparation, design and results of the first QA exercise, involving 16 European laboratories and 10 haemostatic assays. The design allowed the investigation, for each assay, of the variability between duplicates and the variability between days within each centre, and of the agreement between centres. A graphical presentation of each centre's performance in comparison to that of others was adopted, which preserved the confidentiality of each centre's results. The factor VIII clotting activity assay (VIII:C) and the rocket immuno-electrophoresis assays of von Willebrand factor related antigen (vWF R:Ag), antithrombin III, protein C and histidine-rich glycoprotein showed the highest between-duplicate and between-day coefficients of variation (CVs), whereas the clotting assays of activated partial thromboplastin time and fibrinogen had the lowest CVs. CVs for the enzymatic assays using synthetic substrates of antithrombin III, plasminogen and alpha-2-antiplasmin were between these extremes. The between-centre CVs were high for both the VIII:C and vWF R:Ag assays. The QA exercise showed that, in multicentre studies involving the measurement of haemostatic factors, it is feasible to undertake analysis locally at each centre.
S G Thompson; F Duckert; F Haverkate; J M Thomson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  61     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-08-25     Completed Date:  1989-08-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  301-6     Citation Subset:  IM    
Dept. of Clinical Epidemiology, Royal Free Hospital Medical School, London, UK.
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MeSH Terms
Angina Pectoris / blood*
Antithrombin III / analysis
Hemostatics / analysis*
Laboratory Techniques and Procedures*
Multicenter Studies as Topic
Prospective Studies
Reproducibility of Results
Thrombosis / blood*
Reg. No./Substance:
0/Hemostatics; 9000-94-6/Antithrombin III

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