| The measurement of extravascular lung density with SPECT imaging and its relationship with ventilatory abnormalities in patients with congestive heart failure. | |
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MedLine Citation:
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PMID: 14569241 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Patients with congestive heart failure (CHF) have increased ventilatory equivalent for carbon dioxide (Ve/VCO(2)), which may contribute to the symptom of exercise-induced hyperpnea. We have developed a technique in which simultaneous blood volume single photon emission computed tomography imaging and transmission tomography are used to measure extravascular lung density (ELD). We investigated the correlation between Ve/VCO(2) and ELD in patients with CHF. METHODS AND RESULTS: Thirteen patients with stable CHF and eleven control subjects were studied. Attenuation-corrected blood volume emission tomography was acquired with simultaneous transmission tomography to measure pulmonary blood volume and total lung density, respectively. Seven CHF patients underwent maximal exercise treadmill testing with online respiratory gas analysis. ELD was calculated as total lung density minus pulmonary blood volume. SPECT and transmission tomography were repeated immediately after exercise. CHF patients had significantly higher total lung density and ELD compared with normal subjects. No differences in pulmonary blood volume were observed. There was a significant inverse correlation between ELD and left ventricular ejection fraction at rest in CHF patients (r = -0.77, P <.001). A strong correlation was also found between post-exercise ELD and Ve/VCO(2) at peak exercise (r = 0.74, P =.008) and at anaerobic threshold (r = 0.67, P =.024). CONCLUSION: Patients with chronic CHF have increased ELD. The correlation between ELD and Ve/VCO(2) suggests that increased lung water may contribute to the ventilatory abnormalities seen in patients with CHF. |
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Authors:
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Eduardo S Darze; Kar-Lai Wong; Joseph R McClellan; Evan Loh; Luis I Araujo |
Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology Volume: 10 ISSN: 1071-3581 ISO Abbreviation: J Nucl Cardiol Publication Date: 2003 Sep-Oct |
Date Detail:
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Created Date: 2003-10-21 Completed Date: 2004-03-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9423534 Medline TA: J Nucl Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 482-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, Hospital of the University of Pennsylvania, Philadelpia, PA 19104, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon
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methods* Adult Aged Exercise Test Female Gated Blood-Pool Imaging / methods Heart Failure / complications, diagnosis, radiography*, radionuclide imaging* Humans Hyperventilation / diagnosis, etiology, radiography, radionuclide imaging Lung / blood supply, radiography*, radionuclide imaging* Male Middle Aged Pulmonary Circulation Reproducibility of Results Respiration Disorders / diagnosis, etiology, radiography*, radionuclide imaging* Sensitivity and Specificity Statistics as Topic Subtraction Technique Tomography, Emission-Computed, Single-Photon / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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