Document Detail

The measurement of endometrial perfusion in norplant users: a pilot study.
MedLine Citation:
PMID:  10783358     Owner:  NLM     Status:  MEDLINE    
The use of progestogens without oestrogen is commonly associated with irregular menstrual bleeding. Oestrogens and progestogens are both thought to influence endometrial perfusion; changes in endometrial perfusion may contribute to vascular fragility and breakdown. In this study, endometrial perfusion was measured using laser-Doppler fluxmetry in women in the secretory phase of the menstrual cycle before and 4-6 weeks after insertion of the low-dose long-acting levonorgestrel contraceptive implant system, Norplant. Endometrial perfusion was also measured in women exposed to Norplant for up to 19 months. There was no significant difference between endometrial perfusion in control cycles (27.2 flux units +/- 5.5, SEM) and at 4-6 weeks after Norplant insertion (16.3 flux units +/- 5.0), a time when irregular bleeding and spotting are common. Endometrial perfusion was no different from controls after longer periods of Norplant exposure (35.7 flux units +/- 7.2). No direct relationships between endometrial perfusion and plasma concentrations of ovarian steroid hormones were demonstrated. Short-term endometrial vasomotion was largely abolished during Norplant exposure.
M Hickey; C Carati; F Manconi; B J Gannon; D Dwarte; I S Fraser
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  15     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-07-20     Completed Date:  2000-07-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1086-91     Citation Subset:  IM    
Imperial College School of Medicine at St Mary's, Norfolk Place, London W2 1PG, UK.
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MeSH Terms
Blood Pressure
Contraceptive Agents, Female / adverse effects,  pharmacology*
Drug Implants
Endometrium / blood supply*,  drug effects
Estradiol / blood
Laser-Doppler Flowmetry
Levonorgestrel / adverse effects,  pharmacology*
Menstrual Cycle / drug effects,  physiology
Ovary / drug effects,  metabolism
Pilot Projects
Progesterone / blood
Time Factors
Uterine Hemorrhage / chemically induced
Reg. No./Substance:
0/Contraceptive Agents, Female; 0/Drug Implants; 50-28-2/Estradiol; 57-83-0/Progesterone; 797-63-7/Levonorgestrel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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