Document Detail


The measurement of central noradrenergic activity in spontaneously hypertensive rats: a comparison of free 3,4-dihydroxyphenylethyleneglycol levels with FLA-63 induced noradrenaline depletion.
MedLine Citation:
PMID:  4020130     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Noradrenergic activity was measured in the brainstem, hypothalamus and thoracic spinal cord of male and female spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats at 6 and 28-36 weeks of age. Two techniques were used, measurement of a major noradrenaline (NA) metabolite, free 3,4-dihydroxyphenylethyleneglycol (DHPG), and measurement of the rate of decline in brain NA levels following dopamine-beta-hydroxylase (DBH) inhibition by FLA-63. There was a good correlation between the changes with age in NA turnover measured by the two techniques. NA levels and NA turnover measured by both techniques fell with age in brainstem and thoracic spinal cord in both SHR and WKY rats. In both strains these falls in turnover were associated with increases in blood pressure. However, the increase in blood pressure in the SHR was greater than in the WKY, even though NA turnover fell to a similar extent in both strains. These data show a difference in the pattern of change in NA levels and turnover in the brainstem and thoracic spinal cord compared to other brain regions and may therefore be related to the development of higher levels of blood pressure in older rats in both strains. They do not offer a simple explanation for the much higher blood pressures seen at all ages in the SHR.
Authors:
L G Howes; R J Summers; P R Rowe; W J Louis
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  3     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-08-27     Completed Date:  1985-08-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  237-42     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide / pharmacology*
Brain Stem / drug effects,  metabolism
Central Nervous System / drug effects,  metabolism*
Dopamine beta-Hydroxylase / antagonists & inhibitors
Female
Glycols / metabolism*
Hypertension / metabolism*
Hypothalamus / drug effects,  metabolism
Imidazoles / pharmacology*
Male
Methoxyhydroxyphenylglycol / analogs & derivatives,  metabolism*
Norepinephrine / metabolism*
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Sex Factors
Spinal Cord / drug effects,  metabolism
Chemical
Reg. No./Substance:
0/Glycols; 0/Imidazoles; 26087-98-9/Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; 3343-19-9/dihydroxyphenylethylene glycol; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol; EC 1.14.17.1/Dopamine beta-Hydroxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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