| The measure of life-time alcohol consumption in patients with cirrhosis: reproducibility and clinical relevance. | |
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MedLine Citation:
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PMID: 8544643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our aims were to design a reproducible method of measuring life-time alcohol consumption in patients with cirrhosis, and to assess the risk of liver decompensation associated with alcohol intake using a case-control design and a multivariate analysis. We studied 439 patients ("cases") with decompensated cirrhosis, and 233 with compensated cirrhosis ("controls"). Mean life-time daily amount and duration of alcohol intake were measured by a standardized questionnaire, whose reproducibility, assessed by interviewing 75 relatives, was 70% for daily alcohol intake and 84% for duration of intake. Better reproducibility was found by re-interviewing patients at discharge from hospital. Daily alcohol intake was significantly higher in males, younger patients and patients with liver decompensation. After stratification according to the average life-time daily alcohol intake, we found a significant increase in the risk of liver decompensation from 125 g ethanol intake per day onwards. No association was found between duration of alcohol intake and risk of liver decompensation. We conclude that alcohol intake can be reliably and reproducibly measured: in patients with cirrhosis, increased alcohol intake is associated with increased risk of liver decompensation, with a significant dose-effect above a daily intake of 125 g ethanol. |
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Authors:
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S Arico; G Galatola; M Tabone; G Corrao; P Torchio; M Valenti; M De la Pierre |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Liver Volume: 15 ISSN: 0106-9543 ISO Abbreviation: Liver Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1996-02-13 Completed Date: 1996-02-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8200939 Medline TA: Liver Country: DENMARK |
Other Details:
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Languages: eng Pagination: 202-8 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, Ospedale Mauriziano Umberto I, Torino, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Alcohol Drinking / adverse effects* Case-Control Studies Female Hepatitis B / complications Humans Italy Liver Cirrhosis, Alcoholic / etiology* Male Middle Aged Questionnaires Regression Analysis Reproducibility of Results Risk Factors Sex Factors Time Factors |
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