Document Detail

The measure of life-time alcohol consumption in patients with cirrhosis: reproducibility and clinical relevance.
MedLine Citation:
PMID:  8544643     Owner:  NLM     Status:  MEDLINE    
Our aims were to design a reproducible method of measuring life-time alcohol consumption in patients with cirrhosis, and to assess the risk of liver decompensation associated with alcohol intake using a case-control design and a multivariate analysis. We studied 439 patients ("cases") with decompensated cirrhosis, and 233 with compensated cirrhosis ("controls"). Mean life-time daily amount and duration of alcohol intake were measured by a standardized questionnaire, whose reproducibility, assessed by interviewing 75 relatives, was 70% for daily alcohol intake and 84% for duration of intake. Better reproducibility was found by re-interviewing patients at discharge from hospital. Daily alcohol intake was significantly higher in males, younger patients and patients with liver decompensation. After stratification according to the average life-time daily alcohol intake, we found a significant increase in the risk of liver decompensation from 125 g ethanol intake per day onwards. No association was found between duration of alcohol intake and risk of liver decompensation. We conclude that alcohol intake can be reliably and reproducibly measured: in patients with cirrhosis, increased alcohol intake is associated with increased risk of liver decompensation, with a significant dose-effect above a daily intake of 125 g ethanol.
S Arico; G Galatola; M Tabone; G Corrao; P Torchio; M Valenti; M De la Pierre
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Liver     Volume:  15     ISSN:  0106-9543     ISO Abbreviation:  Liver     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-02-13     Completed Date:  1996-02-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8200939     Medline TA:  Liver     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  202-8     Citation Subset:  IM    
Division of Gastroenterology, Ospedale Mauriziano Umberto I, Torino, Italy.
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MeSH Terms
Age Factors
Alcohol Drinking / adverse effects*
Case-Control Studies
Hepatitis B / complications
Liver Cirrhosis, Alcoholic / etiology*
Middle Aged
Regression Analysis
Reproducibility of Results
Risk Factors
Sex Factors
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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