| The meanings of markers: ancillary techniques in diagnosis of thyroid neoplasia. | |
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MedLine Citation:
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PMID: 12665648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review article primarily discusses immunohistochemical markers used to aid the diagnosis of thyroid neoplasia. The review concentrates on high molecular weight cytokeratins, cytokertain 19, HBME-1, and galectin-3. Diagnostic uses of proliferation markers such as p27(kip1) and Ki-67 are discussed along with the oncogene ret in relation to papillary carcinomas and PAX8-peroxisome proliferator-activated receptor gamma1 in relation to follicular carcinoma. The diagnostic use of retinoblastoma tumor suppressor gene product is also discussed. The sensitivities and specificities as well as the pitfalls of these techniques are reviewed. On the basis of the literature, the most highly recommended of these markers to aid in diagnosis are HBME-1 and galectin-3. |
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Authors:
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Simon J Raphael |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Endocrine pathology Volume: 13 ISSN: 1046-3976 ISO Abbreviation: Endocr. Pathol. Publication Date: 2002 |
Date Detail:
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Created Date: 2003-03-31 Completed Date: 2003-07-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9009288 Medline TA: Endocr Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 301-11 Citation Subset: IM |
Affiliation:
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Department of Pathology Sunnybrook and Women's College Health Sciences Centre and Department of Pathobiology and Laboratory Medicine, University of Toronto, Toronto, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD44
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analysis Galectin 3 / analysis Glycoproteins / analysis Humans Immunohistochemistry Keratins / analysis Oncogene Proteins / analysis Thyroid Neoplasms / chemistry, diagnosis* Tumor Markers, Biological / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD44; 0/CD44v6 antigen; 0/Galectin 3; 0/Glycoproteins; 0/HBME-1 antigen; 0/Oncogene Proteins; 0/Tumor Markers, Biological; 68238-35-7/Keratins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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