Document Detail

The meaning of the Leydig cell in relation to the etiology of cryptorchidism: An experimental electron-microscopic study.
MedLine Citation:
PMID:  1483     Owner:  NLM     Status:  MEDLINE    
In our electron-microscopic studies of testicular biopsies, both normal and cryptorchid, we found a simple atrophy of the Leydig cell in the cryptorchid testis. Based on experiments by Raynaud1,2 and Jean3 on pregnant mice, we tried to find the reason for changes in the Leydig cell relating to the etiology of cryptorchidism. We found on electron microscopic study of testes in the offspring of pregnant mice treated with estrogen the same atrophy of the Leydig cell as we see in human cryptorchidism. These changes are not evident when estrogen and HCG are given together. We can conclude from this experiment that lack of gonadotropin stimulation leads to the atrophy of Leydig cells. This atrophy then produces a lack of androgen which could be responsible for cryptorchidism.
F Hadziselimovic; B Herzog
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  11     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-03-30     Completed Date:  1976-03-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
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MeSH Terms
Androgens / biosynthesis
Cryptorchidism / chemically induced,  etiology*,  pathology
Estrogens / administration & dosage,  adverse effects
Gonadotropins / biosynthesis
Infant, Newborn
Leydig Cells / pathology*
Maternal-Fetal Exchange
Testis / drug effects,  pathology
Reg. No./Substance:
0/Androgens; 0/Estrogens; 0/Gonadotropins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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