| The mean platelet volume in patients with non-dipper hypertension compared to dippers and normotensives. | |
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MedLine Citation:
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PMID: 20367545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Increased platelet activation plays an important role in the development of atherosclerosis. Mean platelet volume (MPV) is a determinant of platelet activation. In our study, we aimed to determine whether MPV levels are elevated in non-dipper patients compared with dippers and healthy controls. In addition, we tried to find out if MPV levels are correlated with blood pressure measurements in hypertensive patients. METHODS: This cross-sectional study included 56 hypertensive patients; 27 age- and sex-matched healthy volunteers were enrolled to study as a control subjects. Ambulatory blood pressure monitoring was performed for all patients. Hypertensive patients were divided into two groups: 28 dipper patients (10 male, mean age 51 +/-8 years) and 28 non-dipper patients (11 male, mean age 53+/-10 years). MPV was measured in a blood sample collected in EDTA tubes and was also used for whole blood counts in all patients. RESULTS: In non-dipper patients, 24-h systolic blood pressure (141.5+/-10.21 vs 132.3+/-7.7 mmHg, p<0.001), 24-h diastolic blood pressure (88.2+/-8.5 vs 81.0+/-8.2 mmHg, p<0.01) and 24-h average blood pressure (105.7+/-8.5 vs 97.7+/-7.4 mmHg, p<0.001) are significantly higher than dippers. Whereas daytime measurements were similar between dippers and non-dippers, there was a significant difference between each group during night-time measurements (night-time systolic 137.1 +/-11.0 vs 120.2+/-8.0 mmHg, p<0.001; night-time diastolic 85.3+/-8.0 vs 72.8+/-7.9 mmHg, p<0.001). Non-dipper patients (9.61 +/-0.42 fl) demonstrated higher levels of MPV compared with dippers (9.24+/-0.35 fl) and normotensives (8.87+/-0.33 fl) (p<0.001 and p<0.001, respectively). There was significant correlation between MPV and ambulatory diastolic and systolic blood pressure in non-dipper hypertensives. CONCLUSION: Our results suggest that MPV, a determinant of platelet activation, has a positively correlation with blood pressure and elevated in non-dipper compared with dippers and controls. Increased platelet activation could contribute to increase the atherosclerotic risk in non-dipper patients compared with dippers. |
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Authors:
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Tugrul Inanc; Mehmet Gungor Kaya; Mikail Yarlioglues; Idris Ardic; Ibrahim Ozdogru; Ali Dogan; Nihat Kalay; Ertugrul Gunturk; Ozgur Gunebakmaz; Ibrahim Gul; Ramazan Topsakal |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blood pressure Volume: 19 ISSN: 1651-1999 ISO Abbreviation: Blood Press. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-06 Completed Date: 2010-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9301454 Medline TA: Blood Press Country: England |
Other Details:
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Languages: eng Pagination: 81-5 Citation Subset: IM |
Affiliation:
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Erciyes University, Department of Cardiology, Kayseri, Turkey. mtinanc@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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therapeutic use Blood Platelets / pathology* Blood Pressure / physiology Blood Pressure Monitoring, Ambulatory Case-Control Studies Circadian Rhythm / physiology Cross-Sectional Studies Humans Hypertension / blood*, drug therapy, physiopathology Male Middle Aged Platelet Count |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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