Document Detail

A meal rich in oleic acid beneficially modulates postprandial sICAM-1 and sVCAM-1 in normotensive and hypertensive hypertriglyceridemic subjects.
MedLine Citation:
PMID:  17651961     Owner:  NLM     Status:  MEDLINE    
This study investigated whether subjects with permanent activated endothelium have altered soluble forms of intercellular adhesion molecule 1 (sICAM-1) and vascular cell adhesion molecule 1 (sVCAM-1) postprandial response to a high-fat meal and whether this phenomenon is modulated by the nature of dietary fats. Twenty-eight hypertriglyceridemic (14 normotensives and 14 hypertensives) and 14 healthy male subjects were placed in a randomized and crossover design on diets enriched in refined olive oil (ROO) or high-palmitic sunflower oil (HPSO) for a 1-week lead-in period. Thereafter, subjects ate the corresponding fat-rich meal as a breakfast and underwent sampling hourly for 8 h. Plasma triglycerides (TG), sICAM-1 and sVCAM-1 were assayed. sICAM-1 and sVCAM-1 postprandial peak levels were significantly higher and occurred later in hypertriglyceridemic subjects (all P<.001) compared with healthy subjects. ROO meal resulted in smaller areas under the curve for sICAM-1 and sVCAM-1 in hypertriglyceridemic (normotensive and hypertensive) and healthy subjects compared to HPSO meal. Hypertension did not aggravate the postprandial response of TG, sICAM-1 and sVCAM-1. We conclude that the challenge of a meal with ROO appears to have a significant postprandial benefit on sICAM-1 and sVCAM-1 as surrogate markers of endothelial activation and vascular inflammation in healthy and more importantly in hypertriglyceridemic (normotensive and hypertensive) subjects.
Yolanda M Pacheco; Sergio López; Beatriz Bermúdez; Rocío Abia; José Villar; Francisco J G Muriana
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-07-24
Journal Detail:
Title:  The Journal of nutritional biochemistry     Volume:  19     ISSN:  0955-2863     ISO Abbreviation:  J. Nutr. Biochem.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-07     Completed Date:  2008-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010081     Medline TA:  J Nutr Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  200-5     Citation Subset:  IM    
Cellular and Molecular Nutrition, Instituto de la Grasa (CSIC), 41012 Seville, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cross-Over Studies
Dietary Fats, Unsaturated / administration & dosage*
Hypertension / blood*
Hypertriglyceridemia / blood*
Intercellular Adhesion Molecule-1 / blood*
Oleic Acid / administration & dosage*
Vascular Cell Adhesion Molecule-1 / blood*
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Vascular Cell Adhesion Molecule-1; 112-80-1/Oleic Acid; 126547-89-5/Intercellular Adhesion Molecule-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Mechanisms of colorectal and lung cancer prevention by vegetables: a genomic approach.
Next Document:  Dexamethasone and GLP-2 administered to rat dams during pregnancy and lactation have late effects on...