Document Detail

Is maximal acid output useful in identifying relapsing duodenal ulcer patients?
MedLine Citation:
PMID:  3840819     Owner:  NLM     Status:  MEDLINE    
In a group of 94 duodenal ulcer patients consecutively studied and followed-up for 1 year, subjects with maximal acid output (M.A.O.) above 60 mmol/hour (mostly heavy-smoking men), were found to relapse more frequently than those with lower M.A.O. values (72.2% versus 27.6%; p less than 0.0005). A significantly higher relapse rate was also detected in patients treated with maintenance dosages of effective antisecretory drugs (cimetidine, ranitidine, pirenzepine) and presenting M.A.O. over 60 mmol/hour. It is yet to be established whether an alternative therapeutic regime may prove effective in preventing ulcer recurrence in patients with gastric hypersecretion.
G Battaglia; R Farini; F Di Mario; F Vianello; A Piccoli; M Plebani; R Naccarato
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  7     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1986-01-16     Completed Date:  1986-01-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  375-8     Citation Subset:  IM    
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MeSH Terms
Benzodiazepinones / therapeutic use
Cimetidine / therapeutic use
Duodenal Ulcer / diagnosis*
Follow-Up Studies
Gastric Acid / secretion*
Middle Aged
Ranitidine / therapeutic use
Reg. No./Substance:
0/Benzodiazepinones; 28797-61-7/Pirenzepine; 51481-61-9/Cimetidine; 66357-35-5/Ranitidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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