| The matricellular protein thrombospondin-1 globally regulates cardiovascular function and responses to stress via CD47. | |
| | |
MedLine Citation:
|
PMID: 22266027 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Matricellular proteins play diverse roles in modulating cell behavior by engaging specific cell surface receptors and interacting with extracellular matrix proteins, secreted enzymes, and growth factors. Studies of such interactions involving thrombospondin-1 have revealed several physiological functions and roles in the pathogenesis of injury responses and cancer, but the relatively mild phenotypes of mice lacking thrombospondin-1 suggested that thrombospondin-1 would not be a central player that could be exploited therapeutically. Recent research focusing on signaling through its receptor CD47, however, has uncovered more critical roles for thrombospondin-1 in acute regulation of cardiovascular dynamics, hemostasis, immunity, and mitochondrial homeostasis. Several of these functions are mediated by potent and redundant inhibition of the canonical nitric oxide pathway. Conversely, elevated tissue thrombospondin-1 levels in major chronic diseases of aging may account for the deficient nitric oxide signaling that characterizes these diseases, and experimental therapeutics targeting CD47 show promise for treating such chronic diseases as well as acute stress conditions that are associated with elevated thrombospondin-1 expression. |
| | |
Authors:
|
David D Roberts; Thomas W Miller; Natasha M Rogers; Mingyi Yao; Jeffrey S Isenberg |
Related Documents
:
|
16169197 - Inhibitors of arachidonic acid metabolism act synergistically to signal apoptosis in ne... 21847707 - The nonsteroidal anti-inflammatory drug celecoxib suppresses the growth and induces apo... 16412227 - In vitro modulation of inflammatory cytokine and igg levels by extracts of perna canali... 2809417 - Virus-transformed macrophage-like cell line as tool for eicosanoid research. 9343827 - Role of curdlan sulfate in the binding of hiv-1 gp120 to cd4 molecules and the producti... 14985427 - Oxidized galectin-1 stimulates macrophages to promote axonal regeneration in peripheral... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-14 |
Journal Detail:
|
Title: Matrix biology : journal of the International Society for Matrix Biology Volume: - ISSN: 1569-1802 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9432592 Medline TA: Matrix Biol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Published by Elsevier B.V. |
Affiliation:
|
Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Thrombospondin1 in tissue repair and fibrosis: TGF-?-dependent and independent mechanisms.
Next Document: Development of micropatterned surfaces of poly(butylene succinate) by micromolding for guided tissue...