Document Detail

A mathematical simulation of the hyperneas of metabolic CO2 production and inhalation.
MedLine Citation:
PMID:  727289     Owner:  NLM     Status:  MEDLINE    
Mathematical models of the CO2 responsive controller for ventillatory responses to CO2 inhaled and to CO2 introduced in the perpheral tissues are formulated in the context of a controlled system that is a compartmented tissue system with a lung undergoing breathing movements. Equations representing the system are either ordinary difference-differential equations or algebraic equations. If the controller contains three components simulating, respectively, a proportional controller with a set point, a mechanism sensitive to trans-membrane CO2 gradients, and a mechanism responsive to the autocovariance difference in arterial carbon dioxide tension (PaCO2) about 1.2 s apart; and if the neural tissues produce CO2 as a result of their own activity (positive feedback), the entire system responds to metabolic production of CO2 by increasing ventilation in proportion to metabolism while maintaining a constant PaCO2. The same system responds to inhaled CO2 mixtures with ventilation increasing in proportion to increases in PaCO2. The behavior of the model is used to postulate a spatiotemporal hypothesis for the humoral component of respiratory regulation of CO2 exchanges.
W S Yamamoto
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  235     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1978 Nov 
Date Detail:
Created Date:  1979-02-21     Completed Date:  1979-02-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R265-78     Citation Subset:  IM    
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MeSH Terms
Carbon Dioxide / physiology*
Models, Biological*
Tissue Distribution
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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