| A mathematical model to predict CO2 removal in hollow fiber membrane oxygenators. | |
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MedLine Citation:
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PMID: 18347984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A mathematical model has been developed to predict CO(2) removal in hollow fiber membrane oxygenators. The model is analogous to one developed previously for predicting O(2) transfer. A mass transfer correlation was determined in water for O(2) and CO(2) exchange and collapsed onto one universal curve. The correlation was used to predict CO(2) removal in blood by incorporating a 'facilitated diffusivity' to account for the transport of CO(2) present as bicarbonate. The diffusion of bicarbonate greatly increased the ability of the oxygenator to remove CO(2) in blood compared to water. A fiber bundle module was fabricated to test the model predictions. The fiber bundle had a length of 13 cm and a bundle thickness of 0.2 cm. The module was tested in bovine blood at flowrates of 0.75, 1.5, and 2.2 L/min and CO(2) removal rate predictions were within 9% of experimental measurements at all flowrates. The O(2) transfer rate predictions were within 10% of experimental measurements. A second module was manufactured with a bundle of length 4 cm and thickness of 1 cm. The CO(2) removal predictions were within the standard deviation of the experimental measurements. |
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Authors:
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R G Svitek; W J Federspiel |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2008-03-18 |
Journal Detail:
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Title: Annals of biomedical engineering Volume: 36 ISSN: 1521-6047 ISO Abbreviation: Ann Biomed Eng Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-09 Completed Date: 2008-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 992-1003 Citation Subset: IM |
Affiliation:
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McGowan Institute of Regenerative Medicine, University of Pittsburgh, Room 215, McGowan Building, 3025, East Carson Street, Pittsburgh, PA 15203, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carbon Dioxide
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blood*,
isolation & purification* Computer Simulation Computer-Aided Design* Equipment Design Equipment Failure Analysis Microfluidics Models, Theoretical* Oxygen / blood* Oxygenators, Membrane |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL70051/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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