| A mathematical model for the in vitro kinetics of the anti-cancer agent topotecan. | |
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MedLine Citation:
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PMID: 15094319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this paper a compartmental modelling approach is applied to provide a mathematical description of the activity of the anti-cancer agent topotecan, and delivery to its nuclear DNA target following administration. The activity of topotecan in defined buffers is first modelled using a linear two compartment model that then forms the basis of a cell based model for drug activity in live cell experiments. An identifiability analysis is performed before parameter estimation to ensure that the model output (i.e., continuous, perfect and noise-free data) uniquely determines the parameters. Parameter estimation is performed using experimental data which offers concentrations of active and inactive forms of topotecan from high performance liquid chromatography methods. |
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Authors:
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Neil D Evans; Rachel J Errington; Michael Shelley; Graham P Feeney; Michael J Chapman; Keith R Godfrey; Paul J Smith; Michael J Chappell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mathematical biosciences Volume: 189 ISSN: 0025-5564 ISO Abbreviation: Math Biosci Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-04-19 Completed Date: 2004-06-17 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0103146 Medline TA: Math Biosci Country: United States |
Other Details:
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Languages: eng Pagination: 185-217 Citation Subset: IM |
Affiliation:
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School of Engineering, University of Warwick, Coventry CV4 7AL, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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pharmacokinetics* Cell Compartmentation Computer Simulation Drug Administration Schedule Humans Models, Biological* Topotecan / pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 123948-87-8/Topotecan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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