| A mathematical model for the hemoglobin response to iron intake, based on iron absorption measurements from habitually consumed Indian meals. | |
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MedLine Citation:
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PMID: 21970941 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background/Objectives:The prevalence of iron deficiency (ID) and iron deficiency anemia (IDA) is high in India and appear unchanging over decades. To understand the persistence of these disorders, it is critical to measure iron (Fe) absorption from cereal-based Indian meals, its modulation by ID and the time-course of the response of hemoglobin (Hb) to Fe intake.Subjests/Methods:Fe absorption from rice-based meals was measured by the erythrocyte incorporation of the stable isotope label at 14 days in IDA (N=15) and Fe replete (IR) women (N=15). Hb level was used as surrogate for Fe status, and a response curve for Fe absorption versus the Hb level for a rice-based meal was constructed from measured data. This relationship was used as input for a mathematical model that examined the Hb response to different Fe intakes in normal and anemic women.Results:The mean fractional Fe absorption from a rice-based meal in IR and IDA women was 2.7% and 8.3%, respectively. The model predicted that Fe intakes between 20 and 55 mg/day in low-bioavailability diets would result in stable, non-anemic levels of Hb in women over a 1-year period.Conclusion:This mathematical model suggests that with a Fe intake of 20-30 mg/day and a dietary bioavailability of 3-5%, Hb concentration would hover around 12 g/dl with a variability of 0.5 g/dl in pre-menopausal adult women.European Journal of Clinical Nutrition advance online publication, 5 October 2011; doi:10.1038/ejcn.2011.169. |
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Authors:
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P Thankachan; S Kalasuramath; A L Hill; T Thomas; K Bhat; A V Kurpad |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-05 |
Journal Detail:
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Title: European journal of clinical nutrition Volume: - ISSN: 1476-5640 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Nutrition, St John's Research Institute, St John's National Academy of Health Sciences, Bangalore, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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