Document Detail


A mathematical model of erythropoiesis in mice and rats. Part 2: Stimulated erythropoiesis.
MedLine Citation:
PMID:  2790924     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A mathematical model of erythropoietic cell production and its regulation process has been proposed in a preceding paper. It is primarily based on the assumption that the number of cell divisions taking place in the CFU-E and erythropoietic precursor stages is regulated depending on the oxygen supply of the tissue. Quantitative dose-response relationships for in vivo erythropoiesis are suggested. Here, we demonstrate that this model adequately reproduces data obtained in situations of stimulated erythropoiesis in mice and rats. In detail, this implies a quantitative description of the following processes: (1) Changes in tissue oxygen tension (Pto2) following removal of red cells (bleeding, haemolytic anaemia) or increase in plasma volume (dilution anaemia) or decrease in atmospheric oxygen pressure (hypoxia). (2) Pto2 dependent erythropoietin (EPO) production. (3) Dose-response of EPO on erythropoietic amplification (up to two to four additional mitoses). (4) The changes of the marrow transit time. Model simulations are compared with experimental data for changes of erythropoiesis during hypoxia, EPO-injection, and different forms of anaemia. A satisfactory agreement suggests that the model adequately describes and correlates different direct and indirect ways to stimulate erythropoiesis. It quantifies the role and relative contribution of the haematocrit, haemoglobin concentration, atmospheric oxygen pressure, tissue oxygen pressure, and plasma volume as triggers in erythropoietic stimulation under various conditions. Furthermore, the model may allow to optimize the scheme of EPO-administration and to find the maximum increase of erythropoiesis for a given amount of erythropoietin.
Authors:
H E Wichmann; M Loeffler; K Pantel; H Wulff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell and tissue kinetics     Volume:  22     ISSN:  0008-8730     ISO Abbreviation:  Cell Tissue Kinet     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-11-15     Completed Date:  1989-11-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0174107     Medline TA:  Cell Tissue Kinet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  31-49     Citation Subset:  IM    
Affiliation:
Medizinische Universitatsklinik I, Koln, FRG.
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MeSH Terms
Descriptor/Qualifier:
Anemia / physiopathology
Animals
Anoxia / physiopathology
Blood Volume
Erythropoiesis*
Erythropoietin / pharmacology
Hematocrit
Hematopoietic Stem Cells / cytology,  physiology*
Hemorrhage / physiopathology
Mice
Phenylhydrazines / pharmacology
Rats
Reticulocytes / physiology
Chemical
Reg. No./Substance:
0/Phenylhydrazines; 100-63-0/phenylhydrazine; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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