Document Detail

A mathematical model of the circadian phase-shifting effects of exogenous melatonin.
MedLine Citation:
PMID:  23382594     Owner:  NLM     Status:  In-Data-Review    
Melatonin is endogenously produced and released in humans during nighttime darkness and is suppressed by ocular light exposure. Exogenous melatonin is used to induce circadian phase shifts and sleep. The circadian phase-shifting ability of a stimulus (e.g., melatonin or light) relative to its timing may be displayed as a phase response curve (PRC). Published PRCs to exogenous melatonin show a transition from phase advances to delays approximately 1 h after dim light melatonin onset. A previously developed mathematical model simulates endogenous production and clearance of melatonin as a function of circadian phase, light-induced suppression, and resetting of circadian phase by light. We extend this model to include the pharmacokinetics of oral exogenous melatonin and phase-shifting effects via melatonin receptors in the suprachiasmatic nucleus of the mammalian hypothalamus. Model parameters are fit using 2 data sets: (1) blood melatonin concentration following a 0.3- or 5.0-mg dose, and (2) a PRC to a 3.0-mg dose of melatonin. After fitting to the 3.0-mg PRC, the model correctly predicts that, by comparison, the 0.5-mg PRC is slightly decreased in amplitude and shifted to a later circadian phase. This model also reproduces blood concentration profiles of various melatonin preparations that differ only in absorption rate and percentage degradation by first-pass hepatic metabolism. This model can simulate experimental protocols using oral melatonin, with potential application to guide dose size and timing to optimally shift and entrain circadian rhythms.
Emily R Breslow; Andrew J K Phillips; Jean M Huang; Melissa A St Hilaire; Elizabeth B Klerman
Related Documents :
15118224 - Intracellular responses of antennal chordotonal sensilla of the american cockroach.
16957074 - Ambiguous encoding of stimuli by primary sensory afferents causes a lack of independenc...
23946104 - Change point analysis of travel routes reveals novel insights into foraging strategies ...
23825204 - Latitudinal clines: an evolutionary view on biological rhythms.
19905634 - Magic wavelength to make optical lattice clocks insensitive to atomic motion.
24004754 - Vibration induced white-feet: overview and field study of vibration exposure and report...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biological rhythms     Volume:  28     ISSN:  1552-4531     ISO Abbreviation:  J. Biol. Rhythms     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8700115     Medline TA:  J Biol Rhythms     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-89     Citation Subset:  IM    
*Division of Sleep Medicine, Brigham & Women's Hospital, Harvard Medical School, MA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Modeling the effects of the circadian clock on cardiac electrophysiology.
Next Document:  Multimodal analgesia for perioperative pain in three cats.