Document Detail


A mathematical description of pressures in alveolar pores of Kohn.
MedLine Citation:
PMID:  2020168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Small interalveolar holes within the lung are called pores of Kohn. Some researchers have correlated enlarged pore size with diseases, e.g. emphysema, that are characterized by tissue destruction. Mathematical models of the pressures generated in closed, fluid-filled and open, fluid-lined pores demonstrate that pressures capable of rupturing lung tissue can be developed in a pore due to the surface tension and shape of the air-liquid interface. Pore enlargement accompanied by tissue destruction is presented as a possible mechanism for the disease process observed during aging and the development of emphysema in the lung.
Authors:
D F Lu; C Stanley; G Nunez; D Frazer
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of biomechanical engineering     Volume:  113     ISSN:  0148-0731     ISO Abbreviation:  J Biomech Eng     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-05-30     Completed Date:  1991-05-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909584     Medline TA:  J Biomech Eng     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  104-7     Citation Subset:  IM    
Affiliation:
Mechanical and Aerospace Engineering Department, West Virginia University, Morgantown 26506.
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MeSH Terms
Descriptor/Qualifier:
Humans
Lung Diseases / physiopathology
Models, Biological*
Pressure
Pulmonary Alveoli / physiology*
Rupture, Spontaneous

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