| A mathematical description of pressures in alveolar pores of Kohn. | |
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MedLine Citation:
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PMID: 2020168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Small interalveolar holes within the lung are called pores of Kohn. Some researchers have correlated enlarged pore size with diseases, e.g. emphysema, that are characterized by tissue destruction. Mathematical models of the pressures generated in closed, fluid-filled and open, fluid-lined pores demonstrate that pressures capable of rupturing lung tissue can be developed in a pore due to the surface tension and shape of the air-liquid interface. Pore enlargement accompanied by tissue destruction is presented as a possible mechanism for the disease process observed during aging and the development of emphysema in the lung. |
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Authors:
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D F Lu; C Stanley; G Nunez; D Frazer |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Journal of biomechanical engineering Volume: 113 ISSN: 0148-0731 ISO Abbreviation: J Biomech Eng Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-05-30 Completed Date: 1991-05-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7909584 Medline TA: J Biomech Eng Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 104-7 Citation Subset: IM |
Affiliation:
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Mechanical and Aerospace Engineering Department, West Virginia University, Morgantown 26506. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Humans Lung Diseases / physiopathology Models, Biological* Pressure Pulmonary Alveoli / physiology* Rupture, Spontaneous |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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