Document Detail


A mathematical approach to the analysis of diversity in antibody gene families.
MedLine Citation:
PMID:  823938     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this article, we develop a mathematical approach for the analysis of diversity in antibody gene families. This approach is arrived at by examing two general questions about protein populations: (1) What is a relative measure of the diversity exhibited by one protein family when compared with a second? (2) What is the probability that two protein populations were derived from a single common population? These quantitative approaches permit a variety of precise evolutionary, genetic, and developmental questions to be asked of antibody gene families. Using this methodology, we demonstrate that the diversity in mouse K-immunoglobulin chains is considerably greater than in their human K counterparts. We also show that the variable (Vl) regions of light chains associated with IgG and IgA immunoglobulins in the mouse appear to have been derived from a common population of Vl genes. This approach also can be used to analyse sequence data from other informational multigene families.
Authors:
J M Hood; E Y Loh; L Hood
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical genetics     Volume:  14     ISSN:  0006-2928     ISO Abbreviation:  Biochem. Genet.     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-11-21     Completed Date:  1976-11-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0126611     Medline TA:  Biochem Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  467-79     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Antibodies*
Cell Line
Humans
Immunoglobulin A
Immunoglobulin G
Immunoglobulin Light Chains
Immunoglobulin kappa-Chains
Mathematics
Mice
Mice, Inbred BALB C
Molecular Biology*
Species Specificity
Chemical
Reg. No./Substance:
0/Antibodies; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin Light Chains; 0/Immunoglobulin kappa-Chains

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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