Document Detail


The maternal transfer of bacteria can mediate trans-generational immune priming in insects.
MedLine Citation:
PMID:  24603099     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Parents invest in their offspring by preparing them for defense against pathogens and parasites that only the parents have encountered, a phenomenon known as trans-generational immune priming. We investigated the underlying mechanism using the established lepidopteran model host Galleria mellonella. When larvae were fed with non-pathogenic bacteria, or the entomopathogenic species Pseudomonas entomophila and Serratia entomophila, the activity of lysozyme and phenoloxidase increased in the hemolymph, and immunity-related genes encoding antibacterial proteins such as gloverin were induced. Remarkably, the ingestion of bacteria by female larvae resulted in the differential expression of immunity-related genes in the eggs subsequently laid by the same females, providing evidence for trans-generational immune priming in G. mellonella. To determine the fate of these ingested microbes, the larval diet was supplemented with bacteria carrying a fluorescent label. We observed these bacteria crossing the midgut epithelium, their entrapment within nodules in the hemocoel, their accumulation within the ovary, and ultimately their deposition in the eggs. Therefore, we propose that trans-generational immune priming in Lepidoptera can be mediated by the maternal transfer of bacterial fragments to the developing eggs.
Authors:
Dalial Freitak; Henrike Schmidtberg; Franziska Dickel; Günther Lochnit; Heiko Vogel; Andreas Vilcinskas
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-06
Journal Detail:
Title:  Virulence     Volume:  5     ISSN:  2150-5608     ISO Abbreviation:  Virulence     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101531386     Medline TA:  Virulence     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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