Document Detail


The maternal lifestyle study: cognitive, motor, and behavioral outcomes of cocaine-exposed and opiate-exposed infants through three years of age.
MedLine Citation:
PMID:  15173491     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the direct effects of prenatal cocaine exposure and prenatal opiate exposure on infant mental, motor, and behavioral outcomes longitudinally between 1 and 3 years old. METHODS: As part of a prospective, longitudinal, multisite study, the Bayley Scales of Infant Development II were administered to 1227 infants who were exposed to cocaine (n = 474), opiates (n = 50), cocaine and opiates (n = 48), and neither substance (n = 655) at 1, 2, and 3 years of corrected age by certified, masked examiners. Hierarchic linear modeling of the 1-, 2-, and 3-year scores was conducted using cocaine and opiate exposure as predictors with and without controlling for covariates. RESULTS: Overall retention was 88.4% and did not differ by cocaine or opiate exposure. Overall (at 1, 2, and 3 years), cocaine-exposed infants scored 1.6 Mental Development Index points below infants who were not exposed to cocaine. Opiate-exposed infants scored 3.8 Psychomotor Development Index points below infants who were not exposed to opiates. Neither the cocaine nor the opiate effect remained significant after controlling for covariates. Neither cocaine nor opiate exposure was associated with the Behavioral Record Score during the examination. Low birth weight and indices of nonoptimal caregiving were associated with lower Mental Development Index, Psychomotor Development Index, and Behavioral Record Score scores for all groups of infants. CONCLUSIONS: In the largest at-risk sample observed longitudinally to date, infant prenatal exposure to cocaine and to opiates was not associated with mental, motor, or behavioral deficits after controlling for birth weight and environmental risks.
Authors:
Daniel S Messinger; Charles R Bauer; Abhik Das; Ron Seifer; Barry M Lester; Linda L Lagasse; Linda L Wright; Seetha Shankaran; Henrietta S Bada; Vincent L Smeriglio; John C Langer; Marjorie Beeghly; W Kenneth Poole
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  113     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-02     Completed Date:  2004-09-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1677-85     Citation Subset:  AIM; IM    
Affiliation:
Department of Psychology, University of Miami, Coral Gables, Florida, USA. dmessinger@miami.edu
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MeSH Terms
Descriptor/Qualifier:
Child Behavior / drug effects*
Child Development / drug effects
Child, Preschool
Cocaine / adverse effects*
Female
Humans
Infant
Intelligence / drug effects*
Linear Models
Longitudinal Studies
Motor Skills / drug effects*
Narcotics / adverse effects*
Pregnancy
Prenatal Exposure Delayed Effects*
Grant Support
ID/Acronym/Agency:
N01-HD-2-3159/HD/NICHD NIH HHS; U10 HD 21385/HD/NICHD NIH HHS; U10 HD 21397/HD/NICHD NIH HHS; U10 HD 21415/HD/NICHD NIH HHS; U10 HD 27904/HD/NICHD NIH HHS; U10 HD 36790/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Narcotics; 50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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