| The maternal cortisol awakening response in human pregnancy is associated with the length of gestation. | |
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MedLine Citation:
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PMID: 19716542 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to examine the relationship between intraindividual changes in cortisol responsiveness over pregnancy and the length of human gestation. STUDY DESIGN: Pregnancy-related changes in the cortisol awakening response (CAR), which is a measure of hypothalamic-pituitary-adrenal axis responsiveness, were assessed prospectively in 101 pregnant women at 16.8 +/- 1.4 weeks' and 31.4 +/- 1.3 weeks' (+/-SD) gestation. Cortisol was measured in saliva that was collected immediately and +30, +45 and +60 minutes after awakening. RESULTS: The CAR was significant in pregnancy and exhibited progressive attenuation over the course of gestation. A larger CAR in late pregnancy and reduced attenuation of the CAR from early to late gestation were associated significantly with shorter gestational length. CONCLUSION: The findings are the first to suggest that the hormonal (cortisol) response to a naturally occurring challenge (awakening) and the degree of attenuation of this response over the course of gestation may represent a novel biomarker of increased vulnerability for earlier birth. |
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Authors:
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Claudia Buss; Sonja Entringer; Jonazary F Reyes; Aleksandra Chicz-DeMet; Curt A Sandman; Feizal Waffarn; Pathik D Wadhwa |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-08-29 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 201 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-30 Completed Date: 2009-10-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 398.e1-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychiatry and Human Behavior, University of California, Irvine, School of Medicine, Irvine, CA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Gestational Age Humans Hydrocortisone / analysis* Hypothalamo-Hypophyseal System / physiology Pituitary-Adrenal System / physiology Pregnancy / metabolism* Saliva / chemistry Stress, Psychological / metabolism Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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HD-041696/HD/NICHD NIH HHS; HD-047609/HD/NICHD NIH HHS; HD-33506/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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