Document Detail


The maternal cortisol awakening response in human pregnancy is associated with the length of gestation.
MedLine Citation:
PMID:  19716542     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to examine the relationship between intraindividual changes in cortisol responsiveness over pregnancy and the length of human gestation.
STUDY DESIGN: Pregnancy-related changes in the cortisol awakening response (CAR), which is a measure of hypothalamic-pituitary-adrenal axis responsiveness, were assessed prospectively in 101 pregnant women at 16.8 +/- 1.4 weeks' and 31.4 +/- 1.3 weeks' (+/-SD) gestation. Cortisol was measured in saliva that was collected immediately and +30, +45 and +60 minutes after awakening.
RESULTS: The CAR was significant in pregnancy and exhibited progressive attenuation over the course of gestation. A larger CAR in late pregnancy and reduced attenuation of the CAR from early to late gestation were associated significantly with shorter gestational length.
CONCLUSION: The findings are the first to suggest that the hormonal (cortisol) response to a naturally occurring challenge (awakening) and the degree of attenuation of this response over the course of gestation may represent a novel biomarker of increased vulnerability for earlier birth.
Authors:
Claudia Buss; Sonja Entringer; Jonazary F Reyes; Aleksandra Chicz-DeMet; Curt A Sandman; Feizal Waffarn; Pathik D Wadhwa
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-08-29
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  201     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-30     Completed Date:  2009-10-22     Revised Date:  2013-07-01    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  398.e1-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Psychiatry and Human Behavior, University of California, Irvine, School of Medicine, Irvine, CA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Gestational Age
Humans
Hydrocortisone / analysis*
Hypothalamo-Hypophyseal System / physiology
Pituitary-Adrenal System / physiology
Pregnancy / metabolism*
Saliva / chemistry
Stress, Psychological / metabolism
Young Adult
Grant Support
ID/Acronym/Agency:
HD-041696/HD/NICHD NIH HHS; HD-047609/HD/NICHD NIH HHS; HD-33506/HD/NICHD NIH HHS; P01 HD047609/HD/NICHD NIH HHS; R01 HD041696/HD/NICHD NIH HHS; R29 HD033506/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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