| Is maternal alcohol use a risk factor for early-onset sepsis in premature newborns? | |
| | |
MedLine Citation:
|
PMID: 15528011 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Because chronic alcohol abuse alters immune defenses and increases infection in adults, we tested the hypothesis that maternal alcohol use during pregnancy would increase the risk of sepsis in very low birth weight (VLBW) premature newborns. We performed a case-controlled analysis of VLBW newborns born at Grady Memorial Hospital (Atlanta, GA). Alcohol exposure, as the predictive variable, was assessed by maternal self-report. The outcome variables were early-onset and multiple late-onset sepsis. Univariate analysis with Fisher exact test and multivariate analysis with the use of binary logistic regression were performed. Early-onset sepsis was 15-fold higher in the alcohol-exposed group (n=20) compared with findings for the matched control group (n=168) [alcohol-exposed group, 10%, vs. control group, 0.6%: odds ratio (OR) 6.8 (95% confidence interval [CI], 2.7-17.1), P < or = .05]. Early-onset sepsis in the alcohol+cocaine-exposed group (n=64) did not differ from findings for the control group. The prevalence of multiple late-onset sepsis did not differ among the exposure groups. Logistic regression analysis, controlling for chorioamnionitis and premature prolonged rupture of membranes, demonstrated an independent, increased risk of early-onset sepsis with alcohol exposure [OR 16 (95% CI, 1.2-210), P < or = .05]. We conclude that alcohol exposure significantly increased the risk of early-onset sepsis in this group of VLBW newborns. The effects of maternal alcohol abuse during pregnancy on the risk of infection in the VLBW newborn require further analysis. |
| | |
Authors:
|
Theresa W Gauthier; Martha H Manar; Lou Ann S Brown |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Alcohol (Fayetteville, N.Y.) Volume: 33 ISSN: 0741-8329 ISO Abbreviation: Alcohol Publication Date: 2004 Jun |
Date Detail:
|
Created Date: 2004-11-05 Completed Date: 2005-03-29 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8502311 Medline TA: Alcohol Country: United States |
Other Details:
|
Languages: eng Pagination: 139-45 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA. tgauthi@emory.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Alcohol Drinking / adverse effects* Chorioamnionitis / epidemiology Female Fetal Membranes, Premature Rupture / epidemiology Humans Infant, Newborn Infant, Premature / physiology* Infant, Very Low Birth Weight Male Pregnancy Risk Factors Sepsis / epidemiology* Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
|
R01 AA013979/AA/NIAAA NIH HHS; R03 HD39651/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of vitamin E, sodium selenite, and astrocyte-conditioned medium on neuronal survival after...
Next Document: Ethanol suppresses cytokine responses induced through Toll-like receptors as well as innate resistan...