| The matches, achieved by natural selection, between biological capacities and their natural loads. | |
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MedLine Citation:
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PMID: 1612134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Natural selection tends to eliminate unutilized capacities because of their costs. Hence we ask how large are the reserve capacities by which biological capacities exceed natural loads, and how closely are related biological capacities matched to each other. Measured capacities (Vmax values) of small intestinal brush-border nutrient transporters are typically around twice their natural loads (dietary intakes of their substrates); the ratio is higher for a transporter of a hyperessential nutrient. Preliminary evidence suggests matching of capacities between different steps in carbohydrate metabolism, and between the intestine, liver, kidneys, and spleen. Symmorphosis - the postulated matching of capacities to each other and to loads - is a testable hypothesis of economic design, useful in detecting and explaining cases of apparently uneconomic design. |
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Authors:
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J Diamond; K Hammond |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Experientia Volume: 48 ISSN: 0014-4754 ISO Abbreviation: Experientia Publication Date: 1992 Jun |
Date Detail:
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Created Date: 1992-07-30 Completed Date: 1992-07-30 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0376547 Medline TA: Experientia Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 551-7 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of California Medical School, Los Angeles 90024-1751. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carrier Proteins / metabolism Cold Temperature Dietary Carbohydrates / metabolism Female Hydrolases / metabolism Intestinal Absorption* Intestine, Small / metabolism Lactation Mice Microvilli / metabolism Models, Biological Pregnancy Selection, Genetic* |
| Grant Support | |
ID/Acronym/Agency:
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DK 42973/DK/NIDDK NIH HHS; GM 14772/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Dietary Carbohydrates; EC 3.-/Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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