Document Detail


The mastoparanogen from wasp.
MedLine Citation:
PMID:  17046111     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mastoparans are a family of small peptides identified from the venom of hymenopteroid insects. Although they have been characterized as early as 1979, and so far are recognized as a leading biomolecule in potential drug therapy, their precursors, mastoparanogen, have still not been determined. In this paper, several mastoparans from the venom of the wasp Vespa magnifica (Smith) are reported. The cDNA of mastoparanogen is 236 base pairs in length, and encodes 40 amino acid residues, including a N-terminal acidic fragment and a C-terminal mature basic mastoparan, which contain multiple acidic amino acid residues and a tetradecapeptide with three lysines, INLKAIAALAKKLLG, respectively. The glycine at the tetradecapeptide end is the donator of -NH(4) for the amidation of the leucine at the C-terminal. As far as we know, this is the first report of the precursor of animal mastoparan.
Authors:
Xueqing Xu; Hailong Yang; Haining Yu; Jianxu Li; Ren Lai
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-13
Journal Detail:
Title:  Peptides     Volume:  27     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-20     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3053-7     Citation Subset:  IM    
Affiliation:
Biotoxin Units of Key Laboratories of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Base Sequence
Candida albicans / drug effects,  growth & development
Escherichia coli / drug effects,  growth & development
Microbial Sensitivity Tests
Molecular Sequence Data
Peptides / chemistry*,  isolation & purification,  physiology*
Protein Precursors / chemistry*,  isolation & purification,  physiology*
Staphylococcus aureus / drug effects,  growth & development
Wasp Venoms / chemistry*,  isolation & purification
Wasps / chemistry*,  physiology*
Chemical
Reg. No./Substance:
0/Peptides; 0/Protein Precursors; 0/Wasp Venoms; 72093-21-1/mastoparan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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