| The mast cell: a neuroimmunoendocrine master player. | |
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MedLine Citation:
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PMID: 8880375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review of the literature on mast cells (MC) suggests that when activated they may play a central role in disease syndromes with a neural, immune and endocrine component exacerbated under stress. After a discussion of their biology, differential secretions and interaction with neurons, the effect of stress in causing MC degranulation is emphasized. The importance of MC in syndromes such as migraine, multiple sclerosis, interstitial cystitis and irritable bowel syndrome is assessed, along with possible therapeutic possibilities with compounds that inhibit MC activation. |
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Authors:
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T C Theoharides |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: International journal of tissue reactions Volume: 18 ISSN: 0250-0868 ISO Abbreviation: Int J Tissue React Publication Date: 1996 |
Date Detail:
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Created Date: 1997-01-28 Completed Date: 1997-01-28 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8302116 Medline TA: Int J Tissue React Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 1-21 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Colonic Diseases, Functional / physiopathology Cystitis, Interstitial / physiopathology Female Humans Male Mast Cells / cytology, physiology*, secretion Migraine Disorders / physiopathology Multiple Sclerosis / physiopathology Neurofibromatoses / physiopathology Neuroimmunomodulation / physiology Neurons / cytology, physiology Scleroderma, Systemic / physiopathology Stress, Physiological / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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DK42409/DK/NIDDK NIH HHS; DK44816/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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