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The masculinization of the fetus during pregnancy due to inhalation of diesel exhaust.
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MedLine Citation:
PMID:  11266319     Owner:  NLM     Status:  MEDLINE    
This study was conducted to determine the impact of diesel exhaust inhalation on the fetus. Seventy-two pregnant rats and 18 nonpregnant rats were divided into three groups: a group exposed to total diesel engine exhaust containing 5.63 mg/m(3) particulate matter, 4.10 ppm nitrogen dioxide, and 8.10 ppm nitrogen oxide; a group exposed to filtered exhaust without particulate matter; and a group exposed to clean air. The exposure period was from day 7 until day 20 of pregnancy. In addition, 15 pregnant rats were treated with aromatase inhibitors or testosterone to clarify the process by which diesel exhaust exerts its toxicity. The anogenital distance was significantly longer in male and female fetuses from both exhaust-exposed groups than in those of the control. Differentiation of the testis, ovary, and thymus was delayed and disturbed. Maternal testosterone and progesterone levels, which increased due to pregnancy whether or not the rats were exposed, were significantly higher and lower, respectively, in the pregnant rats exposed to total exhaust and filtered exhaust. The serum adrenocorticotropic hormone (ACTH) level and urinary excretion of 17-hydroxycorticosteroids (OHCS) did not differ among the pregnant groups. These results indicate that elevated testosterone did not result from elevated maternal adrenal function. The feto-placental-ovarian unit and inhibition of aromatase activity and synthesis caused by diesel exhaust inhalation might have played an essential role in the accumulation of testosterone. Since both exhaust-exposed groups showed almost the same reactions toward the inhalation, the gaseous phase must have included the relevant toxicants.
N Watanabe; M Kurita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental health perspectives     Volume:  109     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-27     Completed Date:  2001-05-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111-9     Citation Subset:  IM    
Department of Environmental Health, Tokyo Metropolitan Research Laboratory of Public Health, Tokyo, Japan.
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MeSH Terms
Adrenal Glands / physiology
Adrenocorticotropic Hormone / blood
Aromatase Inhibitors
Body Weight / drug effects
Embryo Implantation
Enzyme Inhibitors / administration & dosage
Estrogens / blood
Fetus / drug effects*
Inhalation Exposure*
Litter Size
Ovary / physiology
Progesterone / blood
Rats, Inbred F344
Sex Ratio*
Testosterone / administration & dosage,  blood
Vehicle Emissions / toxicity*
Reg. No./Substance:
0/Aromatase Inhibitors; 0/Enzyme Inhibitors; 0/Estrogens; 0/Vehicle Emissions; 57-83-0/Progesterone; 58-22-0/Testosterone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 2 Year: 2001
Volume: 109 Issue: 2
First Page: 111 Last Page: 119
ID: 1240629
PubMed Id: 11266319
Publisher Item Identifier: sc271_5_1835

The masculinization of the fetus during pregnancy due to inhalation of diesel exhaust.
N Watanabe
M Kurita
Department of Environmental Health, Tokyo Metropolitan Research Laboratory of Public Health, Tokyo, Japan.

Article Categories:
  • Research Article

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