| A marker of terminal stalk cell terminal differentiation in Dictyostelium. | |
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MedLine Citation:
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PMID: 9203345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe the isolation of staB, a Dictyostelium gene that is selectively expressed in stalk cells. If an aggregate enters culmination immediately staB is expressed in the bottom half of the stalk and in the basal disc but if a migratory slug is formed it is also expressed in the top of the stalk and in a disc of cells that surmounts the spore head. The latter two populations of cells derive from the rear part of the prestalk region, the pstO cells, which would therefore seem to change their transcriptional competency during slug migration. The staB promoter contains a distal region that is required for expression within both the stalk and the basal disc and a proximal region that is required only for expression within the basal disc. This uncoupling of transcriptional specificities suggests that the signalling mechanisms that direct terminal differentiation in these two tissues differ in some way. |
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Authors:
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V Robinson; J Williams |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Differentiation; research in biological diversity Volume: 61 ISSN: 0301-4681 ISO Abbreviation: Differentiation Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-08-13 Completed Date: 1997-08-13 Revised Date: 2009-09-29 |
Medline Journal Info:
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Nlm Unique ID: 0401650 Medline TA: Differentiation Country: GERMANY |
Other Details:
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Languages: eng Pagination: 223-8 Citation Subset: IM |
Affiliation:
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Imperial Cancer Research Fund, Clare Hall Laboratory, S. Mimms, Herts, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Base Sequence Cell Differentiation / genetics Cloning, Molecular Dictyostelium / cytology*, genetics* Fungal Proteins / genetics* Gene Expression Regulation, Fungal Genes, Fungal Genetic Markers Molecular Sequence Data Promoter Regions, Genetic Protozoan Proteins* Recombinant Fusion Proteins / genetics, metabolism Sequence Analysis, DNA beta-Galactosidase / genetics |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Fungal Proteins; 0/Genetic Markers; 0/Protozoan Proteins; 0/Recombinant Fusion Proteins; 0/StaB protein, Dictyostelium; EC 3.2.1.23/beta-Galactosidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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