Document Detail


A marked drop in the incidence of the null allele of the B gene of the fourth component of complement (C4B*Q0) in elderly subjects: C4B*Q0 as a probable negative selection factor for survival.
MedLine Citation:
PMID:  2026423     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of allotypes of the genes of the fourth component (C4) and factor B of the complement system was compared in 252 persons under 45 years of age ("young" group) with 482 people between 61 and 90 years of age ("old" group). One hundred people older than 90 years of age (nonagenarians) were also investigated. A striking difference was found between the "young" and "old" groups in the incidence (16.1% and 5.4%, respectively) of a silent gene of the C4B allele (C4B*Q0). This difference was even more marked among "young" and "old" men (17.6% vs 3.4%). The incidence of the C4B*Q0 allele in women dropped to the level of the men only in the nonagenarian group. The most probable explanation for this finding is that people carrying the C4B*Q0 allele die from as yet unidentified disease(s) in their middle-age. Therefore, male (and to a lesser extent female) carriers of this allele may have a considerably shorter life expectancy than individuals without a silent gene in the C4B locus.
Authors:
J Kramer; T Fülöp; K Rajczy; A T Nguyen; G Füst
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human genetics     Volume:  86     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-06-10     Completed Date:  1991-06-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  595-8     Citation Subset:  IM    
Affiliation:
Department of Immunopathology, National Institute of Haematology and Blood Transfusion, Budapest, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Aging / genetics*
Alleles
Chi-Square Distribution
Complement C4b / genetics*
Female
Gene Frequency
Humans
Longevity / genetics*
Male
Middle Aged
Selection, Genetic*
Chemical
Reg. No./Substance:
80295-50-7/Complement C4b

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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