Document Detail

A marked drop in the incidence of the null allele of the B gene of the fourth component of complement (C4B*Q0) in elderly subjects: C4B*Q0 as a probable negative selection factor for survival.
MedLine Citation:
PMID:  2026423     Owner:  NLM     Status:  MEDLINE    
The incidence of allotypes of the genes of the fourth component (C4) and factor B of the complement system was compared in 252 persons under 45 years of age ("young" group) with 482 people between 61 and 90 years of age ("old" group). One hundred people older than 90 years of age (nonagenarians) were also investigated. A striking difference was found between the "young" and "old" groups in the incidence (16.1% and 5.4%, respectively) of a silent gene of the C4B allele (C4B*Q0). This difference was even more marked among "young" and "old" men (17.6% vs 3.4%). The incidence of the C4B*Q0 allele in women dropped to the level of the men only in the nonagenarian group. The most probable explanation for this finding is that people carrying the C4B*Q0 allele die from as yet unidentified disease(s) in their middle-age. Therefore, male (and to a lesser extent female) carriers of this allele may have a considerably shorter life expectancy than individuals without a silent gene in the C4B locus.
J Kramer; T Fülöp; K Rajczy; A T Nguyen; G Füst
Related Documents :
23307923 - Relationships between age and epi-genotype of the fmr1 exon 1/intron 1 boundary are con...
9137113 - No association between apolipoprotein e epsilon 4 allele and rate of decline in alzheim...
24530593 - Acute embryonic exposure to nanosilver or silver ion does not disrupt the stress respon...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human genetics     Volume:  86     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-06-10     Completed Date:  1991-06-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  595-8     Citation Subset:  IM    
Department of Immunopathology, National Institute of Haematology and Blood Transfusion, Budapest, Hungary.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Aging / genetics*
Chi-Square Distribution
Complement C4b / genetics*
Gene Frequency
Longevity / genetics*
Middle Aged
Selection, Genetic*
Reg. No./Substance:
80295-50-7/Complement C4b

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Two human genes encoding zinc finger proteins, ZNF 12 (KOX 3) and ZNF 26 (KOX 20), map to chromosome...
Next Document:  Effects of the apolipoprotein(a) size polymorphism on the lipoprotein(a) concentration in 7 ethnic g...