Document Detail


The marine toxin domoic acid may affect the developing brain by activation of neonatal brain microglia and subsequent neurotoxic mediator generation.
MedLine Citation:
PMID:  10859697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Amnesic shellfish poisoning, one of the shellfish poisoning syndromes, is caused by the marine diatom toxin domoic acid (DOM). While in adult rats, mice, monkeys and humans DOM poorly penetrates the blood-brain barrier, DOM has been shown to be very toxic to fetal in newborn mice, because the blood-brain barrier is incomplete during neurodevelopment. This fact may explain why neonates show a higher sensitivity to neurotoxins like DOM as compared to adult animals. Mechanistic studies on DOM's neurotoxicity have mainly concentrated on the investigation of DOM's effect on neuronal tissue. Recent studies have shown that glia is also involved in DOM's neurotoxicity to the adult as well as the developing nervous system. The scientific literature strongly supports the hypothesis that the microglia may play a critical role in mediating DOM's neurotoxic effects. However, the effect of DOM on microglia has not been systematically investigated. The literature supporting our hypothesis is presented and discussed.
Authors:
A M Mayer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Medical hypotheses     Volume:  54     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-07-20     Completed Date:  2000-07-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  837-41     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Harcourt Publishers Ltd.
Affiliation:
Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois, USA. amayer@midwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Brain / drug effects*,  embryology,  growth & development
Kainic Acid / analogs & derivatives*,  pharmacology
Marine Toxins / pharmacology*
Mice
Microglia / drug effects*
Neurotoxins / pharmacology*
Rats
Chemical
Reg. No./Substance:
0/Marine Toxins; 0/Neurotoxins; 14277-97-5/domoic acid; 487-79-6/Kainic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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