| The many faces of the contact pathway and their role in thrombosis. | |
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MedLine Citation:
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PMID: 21404067 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Understanding inherent differences between thrombosis and hemostasis in the vascular system are critical to developing safe and effective anticoagulants. To this end, constituents of the contact activated and intrinsic pathway of coagulation appear to be involved in pathological thrombus formation, but are not required for normal hemostasis. In addition to coagulation, activation of the contact system is involved in fibrinolytic, inflammatory, and angiogenic processes that can also contribute to the thrombotic environment. This review discusses the role of the contact system in these processes, and highlights the potential of FXII and FXI as safer targets for antithrombotic therapy. |
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Authors:
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Rebecca S Woodruff; Bruce Sullenger; Richard C Becker |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-15 |
Journal Detail:
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Title: Journal of thrombosis and thrombolysis Volume: - ISSN: 1573-742X ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9502018 Medline TA: J Thromb Thrombolysis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Duke Translational Research Institute, Divisions of Cardiology and Hematology, Duke University School of Medicine, Durham, USA, becky.smock@duke.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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