Document Detail

The many faces of CREB.
MedLine Citation:
PMID:  15982754     Owner:  NLM     Status:  MEDLINE    
The transcription factor CREB is best known for its involvement in learning and memory. However, emerging evidence suggests that CREB activity has very different roles--sometimes beneficial, sometimes detrimental--depending on the brain region involved. Induction of CREB in the hippocampus by antidepressant treatments could contribute to their therapeutic efficacy. By contrast, activation of CREB in the nucleus accumbens and several other regions by drugs of abuse or stress mediates certain aspects of drug addiction, and depressive and anxiety-like behaviors. These complexities suggest that strategies that exploit regional differences in upstream factors or that target specific CREB-regulated genes, rather than CREB itself, could make a promising contribution to the treatment of neuropsychiatric conditions.
William A Carlezon; Ronald S Duman; Eric J Nestler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Trends in neurosciences     Volume:  28     ISSN:  0166-2236     ISO Abbreviation:  Trends Neurosci.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-25     Completed Date:  2005-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7808616     Medline TA:  Trends Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  436-45     Citation Subset:  IM    
Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont MA 02478, USA.
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MeSH Terms
Brain / anatomy & histology,  metabolism*
Cyclic AMP Response Element-Binding Protein / physiology*
Depression / metabolism
Learning / physiology*
Models, Molecular
Models, Neurological
Substance-Related Disorders / metabolism
Reg. No./Substance:
0/Cyclic AMP Response Element-Binding Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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