| The mannose-binding lectin (MBL2) haplotype and breast cancer: an association study in African-American and Caucasian women. | |
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MedLine Citation:
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PMID: 17071626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Common genetic variants in cancer-related genes contribute to breast cancer. The innate immune system plays a crucial role in the immune surveillance against malignancies, thus it is plausible that genetic variations in key genes of the innate immunity such as the mannose-binding lectin (MBL), MBL2, could influence the risk for breast cancer. We investigated the association of MBL2 genotypes with breast cancer and conducted a comprehensive genotype and haplotype analysis of 26 MBL2 single nucleotide polymorphisms (SNPs) in a case-control study of breast cancer [166 African-American (AA) case patients versus 180 controls and 127 Caucasian (CAU) case patients versus 137 controls]. We observed that the A allele of the 3'-UTR SNP Ex4-1067 (NCBI SNP ID: rs10824792) was significantly associated with a decreased disease risk in AA women [odds ratio (OR) = 0.47, 95% confidence interval (CI) = 0.27-0.81]. Haplotype analysis of MBL2 showed that the frequency of the corresponding 3' haplotype TATAAC (Ex4-1483, Ex4-1067, Ex4-1047, Ex4-901, Ex4-710, 3238bp 3' STP) was lower in cases than controls among AA women (0.15 versus 0.21; P = 0.02) suggesting a protective effect after adjusting for covariates (OR = 0.51, 95% CI = 0.29-0.88, P = 0.018). In conclusion, this study presents preliminary evidence that common genetic variants in the 3'-UTR of MBL2 might influence the risk for breast cancer in AA women, probably in interaction with the 5' secretor haplotypes that are associated with high concentrations of MBL. |
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Authors:
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Toralf Bernig; Brenda J Boersma; Tiffany M Howe; Robert Welch; Sunita Yadavalli; Brian Staats; Leah E Mechanic; Stephen J Chanock; Stefan Ambs |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Intramural Date: 2006-10-27 |
Journal Detail:
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Title: Carcinogenesis Volume: 28 ISSN: 0143-3334 ISO Abbreviation: Carcinogenesis Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-30 Completed Date: 2007-05-10 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8008055 Medline TA: Carcinogenesis Country: England |
Other Details:
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Languages: eng Pagination: 828-36 Citation Subset: IM |
Affiliation:
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Section on Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) Bethesda, MD 20892-4258, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3' Untranslated Regions
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genetics African Americans / genetics* Breast Neoplasms / blood, ethnology, genetics* Ethnic Groups / genetics* European Continental Ancestry Group / genetics* Female Genetic Markers Genetic Variation* Haplotypes / genetics* Humans Linkage (Genetics) Mannose-Binding Lectin / blood, genetics* Middle Aged United States / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/3' Untranslated Regions; 0/Genetic Markers; 0/MBL2 protein, human; 0/Mannose-Binding Lectin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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