Document Detail


The mannose-binding lectin (MBL2) haplotype and breast cancer: an association study in African-American and Caucasian women.
MedLine Citation:
PMID:  17071626     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Common genetic variants in cancer-related genes contribute to breast cancer. The innate immune system plays a crucial role in the immune surveillance against malignancies, thus it is plausible that genetic variations in key genes of the innate immunity such as the mannose-binding lectin (MBL), MBL2, could influence the risk for breast cancer. We investigated the association of MBL2 genotypes with breast cancer and conducted a comprehensive genotype and haplotype analysis of 26 MBL2 single nucleotide polymorphisms (SNPs) in a case-control study of breast cancer [166 African-American (AA) case patients versus 180 controls and 127 Caucasian (CAU) case patients versus 137 controls]. We observed that the A allele of the 3'-UTR SNP Ex4-1067 (NCBI SNP ID: rs10824792) was significantly associated with a decreased disease risk in AA women [odds ratio (OR) = 0.47, 95% confidence interval (CI) = 0.27-0.81]. Haplotype analysis of MBL2 showed that the frequency of the corresponding 3' haplotype TATAAC (Ex4-1483, Ex4-1067, Ex4-1047, Ex4-901, Ex4-710, 3238bp 3' STP) was lower in cases than controls among AA women (0.15 versus 0.21; P = 0.02) suggesting a protective effect after adjusting for covariates (OR = 0.51, 95% CI = 0.29-0.88, P = 0.018). In conclusion, this study presents preliminary evidence that common genetic variants in the 3'-UTR of MBL2 might influence the risk for breast cancer in AA women, probably in interaction with the 5' secretor haplotypes that are associated with high concentrations of MBL.
Authors:
Toralf Bernig; Brenda J Boersma; Tiffany M Howe; Robert Welch; Sunita Yadavalli; Brian Staats; Leah E Mechanic; Stephen J Chanock; Stefan Ambs
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Intramural     Date:  2006-10-27
Journal Detail:
Title:  Carcinogenesis     Volume:  28     ISSN:  0143-3334     ISO Abbreviation:  Carcinogenesis     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-30     Completed Date:  2007-05-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  England    
Other Details:
Languages:  eng     Pagination:  828-36     Citation Subset:  IM    
Affiliation:
Section on Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) Bethesda, MD 20892-4258, USA.
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MeSH Terms
Descriptor/Qualifier:
3' Untranslated Regions / genetics
African Americans / genetics*
Breast Neoplasms / blood,  ethnology,  genetics*
Ethnic Groups / genetics*
European Continental Ancestry Group / genetics*
Female
Genetic Markers
Genetic Variation*
Haplotypes / genetics*
Humans
Linkage (Genetics)
Mannose-Binding Lectin / blood,  genetics*
Middle Aged
United States / epidemiology
Chemical
Reg. No./Substance:
0/3' Untranslated Regions; 0/Genetic Markers; 0/MBL2 protein, human; 0/Mannose-Binding Lectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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