Document Detail

The management of temperature during hypothermic cardiopulmonary bypass: II--Effect of prolonged hypothermia.
MedLine Citation:
PMID:  7586104     Owner:  NLM     Status:  MEDLINE    
In animals mild hypothermia (32-35 degrees C) reduces ischaemic brain injury, but this has not been investigated in humans. During hypothermic cardiopulmonary bypass (CPB) patients are made hypothermic (usually to 30-32 degrees C) but are then rewarmed at a time when they are still at risk of ischaemic brain injury. We investigated the feasibility and safety of maintaining mild hypothermia throughout the CPB period. Thirty adult cardiac surgical patients were randomized to either rewarming to 36-37 degrees C or to maintaining temperature at 34 degrees C without rewarming. On arrival in the recovery room, patients in the hypothermic group had a mean bladder temperature of 33.8 +/- 0.45 degrees C compared with 35.4 +/- 0.58 degrees C (mean +/- SD, P < 0.05) in the rewarmed patients. There were no differences between groups in intra- or postoperative blood loss or blood use, inotrope use, dysrhythmias, or myocardial infarction. The hypothermic group received more muscle relaxant for the treatment of shivering postoperatively. Our results suggest that mild hypothermia following CPB did not increase morbidity although larger studies are needed for confirmation.
H J Nathan; T Polis
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  42     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-12-04     Completed Date:  1995-12-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  672-6     Citation Subset:  IM    
Department of Anaesthesia, University of Ottawa Heart Institute, Ontario, Canada.
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MeSH Terms
Arrhythmias, Cardiac / etiology
Blood Loss, Surgical
Blood Transfusion
Body Temperature*
Body Temperature Regulation
Brain Ischemia / etiology
Cardiopulmonary Bypass*
Cardiotonic Agents / therapeutic use
Feasibility Studies
Hypothermia, Induced* / methods
Middle Aged
Myocardial Infarction / etiology
Nasopharynx / physiology
Neuromuscular Nondepolarizing Agents / administration & dosage
Rewarming / adverse effects
Risk Factors
Shivering / drug effects
Time Factors
Tympanic Membrane / physiology
Urinary Bladder / physiology
Vecuronium Bromide / administration & dosage
Reg. No./Substance:
0/Cardiotonic Agents; 0/Neuromuscular Nondepolarizing Agents; 50700-72-6/Vecuronium Bromide
Comment In:
Can J Anaesth. 1995 Aug;42(8):663-8   [PMID:  7586102 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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