Document Detail

The management of pregnancy and pregnancy-related medical conditions in pulmonary arterial hypertension patients.
MedLine Citation:
PMID:  21736676     Owner:  NLM     Status:  In-Data-Review    
Pulmonary arterial hypertension (PAH) is a complex disorder in which pulmonary arterial obstruction leads to elevated pulmonary arterial resistance and right ventricular failure. Normal physiologic changes that occur during pregnancy and immediately postpartum may produce fatal consequence in PAH patients. Pregnancy in patients with PAH has a high maternal mortality, estimated at 30-56%. Contemporary estimates of mortality are better but still prohibitively high. Current guidelines recommend that pregnancy be avoided or terminated early in women with PAH. Some patients, despite counselling by their physician, choose to continue with their pregnancy. In addition, some women first present with PAH during pregnancy leading to complex management issues in a high-risk patient. PAH-specific therapies may allow patients to better tolerate pregnancy. These patients should be treated by experienced physicians at tertiary care centres. This review article will focus on the management of the pregnant PAH patient and the preventative options available for this high-risk cohort.
C-H Hsu; M Gomberg-Maitland; C Glassner; J-H Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical practice     Volume:  65 Suppl 172     ISSN:  1742-1241     ISO Abbreviation:  Int. J. Clin. Pract.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9712381     Medline TA:  Int J Clin Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  6-14     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan Section of Cardiology, University of Chicago Medical Center, Chicago, USA Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
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