| The management of pregnancy in paroxysmal nocturnal haemoglobinuria on long term eculizumab. | |
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MedLine Citation:
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PMID: 20151973 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In Paroxysmal nocturnal haemoglobinuria (PNH), pregnancy is associated with increased maternal and foetal complications to such an extent that the condition has been considered relatively contra-indicated in PNH. Eculizumab has revolutionized the treatment of PNH. We evaluate its use in pregnancy to date. We report on seven patients exposed to eculizumab at different stages of pregnancy including the first two patients to receive the drug from conception to delivery. There was no evidence of complement blockade from cord blood samples taken at delivery. Eculizumab appears safe to use in this setting and is likely to prevent many of the complications usually observed. |
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Authors:
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Richard Kelly; Louise Arnold; Stephen Richards; Anita Hill; Charlotte Bomken; John Hanley; Andrew Loughney; Jon Beauchamp; Gus Khursigara; Russell P Rother; Elizabeth Chalmers; Andrew Fyfe; Edward Fitzsimons; Ryotaro Nakamura; Anna Gaya; Antonio M Risitano; J?rg Schubert; Derek Norfolk; Nigel Simpson; Peter Hillmen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-11 |
Journal Detail:
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Title: British journal of haematology Volume: 149 ISSN: 1365-2141 ISO Abbreviation: Br. J. Haematol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-04 Completed Date: 2010-06-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: England |
Other Details:
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Languages: eng Pagination: 446-50 Citation Subset: IM |
Affiliation:
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Institute of Oncology, St James's University Hospital, Leeds, UK. richardkelly@nhs.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Monoclonal / blood, therapeutic use* Female Fetal Blood / metabolism Hemoglobinuria, Paroxysmal / drug therapy* Humans Maternal-Fetal Exchange Pregnancy Pregnancy Complications, Hematologic / drug therapy* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/eculizumab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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