Document Detail

The management of pregnancy in Wilson's disease treated with trientine.
MedLine Citation:
PMID:  3704107     Owner:  NLM     Status:  MEDLINE    
Seven patients with Wilson's disease, treated with trientine, have been followed during 11 pregnancies. Eight of these resulted in the delivery of normal infants, whilst one was very premature (31 weeks) and was later shown to have a chromosomal defect, isochromosome X. There was one therapeutic termination and one miscarriage associated with a contraceptive coil. The eight children are progressing satisfactorily and have been studied for periods varying from three months to nine years; all mothers are also doing well. The child with the isochromosome X is developing slowly; she shows no morphological abnormalities at this stage. The normal-for-age caeruloplasmin values found in the cord blood indicates that there was no significant copper depletion in the foetuses, as a result of treatment.
J M Walshe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Quarterly journal of medicine     Volume:  58     ISSN:  0033-5622     ISO Abbreviation:  Q. J. Med.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-06-13     Completed Date:  1986-06-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401027     Medline TA:  Q J Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  81-7     Citation Subset:  IM    
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MeSH Terms
Ceruloplasmin / analysis
Copper / blood,  urine
Ethylenediamines / therapeutic use*
Hepatolenticular Degeneration / blood,  drug therapy*,  urine
Pregnancy Complications / blood,  drug therapy*,  urine
Triethylenetetramine / therapeutic use*
Reg. No./Substance:
0/Ethylenediamines; 112-24-3/Triethylenetetramine; 7440-50-8/Copper; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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