Document Detail

The management of metformin overdose.
MedLine Citation:
PMID:  9771180     Owner:  NLM     Status:  MEDLINE    
Only two cases of deliberate self-poisoning with metformin have been described in the literature. We report the management of three cases, all of which presented with severe lactic acidosis. Two cases had a fatal outcome. The options for treatment and previous cases reported in the literature are reviewed. Recommendations for the management of metformin overdose include early recognition, intensive support of the cardiovascular system, the correction of metabolic acidosis and the maintenance of body temperature. The use of venovenous haemofiltration against a non-lactate containing fluid may improve outcome when sodium bicarbonate alone fails to reverse severe systemic acidosis.
K F Teale; A Devine; H Stewart; N J Harper
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Anaesthesia     Volume:  53     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-10-21     Completed Date:  1998-10-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  698-701     Citation Subset:  AIM; IM    
Department of Anaesthesia, Manchester Royal Infirmary, UK.
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MeSH Terms
Acidosis, Lactic / chemically induced*
Diabetes Mellitus, Type 2 / drug therapy
Fatal Outcome
Hypoglycemic Agents / poisoning*
Metformin / poisoning*
Middle Aged
Overdose / therapy
Reg. No./Substance:
0/Hypoglycemic Agents; 657-24-9/Metformin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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