| The management of metformin overdose. | |
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MedLine Citation:
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PMID: 9771180 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Only two cases of deliberate self-poisoning with metformin have been described in the literature. We report the management of three cases, all of which presented with severe lactic acidosis. Two cases had a fatal outcome. The options for treatment and previous cases reported in the literature are reviewed. Recommendations for the management of metformin overdose include early recognition, intensive support of the cardiovascular system, the correction of metabolic acidosis and the maintenance of body temperature. The use of venovenous haemofiltration against a non-lactate containing fluid may improve outcome when sodium bicarbonate alone fails to reverse severe systemic acidosis. |
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Authors:
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K F Teale; A Devine; H Stewart; N J Harper |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Anaesthesia Volume: 53 ISSN: 0003-2409 ISO Abbreviation: Anaesthesia Publication Date: 1998 Jul |
Date Detail:
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Created Date: 1998-10-21 Completed Date: 1998-10-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 698-701 Citation Subset: AIM; IM |
Affiliation:
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Department of Anaesthesia, Manchester Royal Infirmary, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis, Lactic
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chemically induced* Adult Diabetes Mellitus, Type 2 / drug therapy Fatal Outcome Female Humans Hypoglycemic Agents / poisoning* Male Metformin / poisoning* Middle Aged Overdose / therapy |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 657-24-9/Metformin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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