Document Detail

The management of idiopathic thrombotic microangiopathy. Changing trends.
MedLine Citation:
PMID:  11100895     Owner:  NLM     Status:  MEDLINE    
Thrombotic microangiopathy, including the two related syndromes thrombotic thrombocytopenic purpura and hemolytic-uremic syndrome, is a rare and severe multisystem disorder, due to widespread deposition of intravascular microthrombi consisting mainly of platelets, with subsequent consumption thrombocytopenia, microangiopathic hemolytic anemia, renal abnormalities, and neurologic disturbances. The epidemic, verotoxin-induced hemolytic-uremic syndrome, typically associated with prodromal diarrhea, mainly affects young children in small outbreaks. By contrast, idiopathic thrombotic microangiopathy generally affects adults in a sporadic form; it has a more devastating course and a less favourable outcome. Over 90% of the reported cases in the adult, when untreated, have progressed to death within three months of diagnosis. Since the introduction of plasma exchange, a dramatic change in the prognosis of the disease has taken place, although the mortality rate still remains considerable. Indeed, improved survival is the most striking feature of adult thrombotic microangiopathy compared to some decades ago. In the present article we will focus on the evolving concepts able to exert a considerable impact in the management of the adult idiopathic form of thrombotic microangiopathy.
A Sagripanti; L M Sarteschi; A Carpi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie     Volume:  54     ISSN:  0753-3322     ISO Abbreviation:  Biomed. Pharmacother.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-06-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8213295     Medline TA:  Biomed Pharmacother     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  423-30     Citation Subset:  IM    
Dept. of Internal Medicine, University Hospital, Pisa, Italy.
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MeSH Terms
Hemolytic-Uremic Syndrome / complications,  diagnosis,  therapy*
Iloprost / pharmacology,  therapeutic use
Multiple Organ Failure / etiology,  therapy*
Plasma Exchange*
Platelet Aggregation / drug effects,  physiology
Platelet Aggregation Inhibitors / pharmacology,  therapeutic use*
Purpura, Thrombotic Thrombocytopenic / complications,  diagnosis,  therapy*
Thrombosis / complications,  diagnosis,  therapy
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; 78919-13-8/Iloprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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