| The management of acute heart failure. | |
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MedLine Citation:
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PMID: 20228726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hospitalization for acute heart failure (AHF) is one of the burdensome aspects of 21st century medicine, leading to significant debilitating symptoms, high morbidity and mortality and consuming significant portion of the health care budget. Management of AHF is thought-provoking given the heterogeneity of the patient population, absence of a universally accepted definition, incomplete understanding of the pathophysiology and the beneficial and adverse effects of currently used therapies and lack of robust evidence-based guidelines. The article will discuss the clinical approach to the patients admitted with AHF, reviewing types of intervention (both approved and investigational) and will delineate their role and timing in specific AHF presentations. One of the challenges of AHF management is to effectively treat the subsets of patients with slow improvement or those with refractory AHF or early recurrence (worsening HF) during their initial admission. Unfortunately, the majority of these patients are at increased risk for subsequent complications and adverse outcomes. Therefore, considerable efforts in AHF management should be directed towards this population. Regretfully, to date no specific targeted therapy was proven beneficial for these patients, being one of the leading reasons for the lack of improvement in AHF outcomes over the last 30 years. |
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Authors:
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O Milo-Cotter; L Bettari; L Kleijn; S Bugatti; C Lombardi; M Rund; M Metra; A A Voors; G Cotter; E Kaluski; B D Weatherley |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Panminerva medica Volume: 52 ISSN: 1827-1898 ISO Abbreviation: Panminerva Med Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-07-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0421110 Medline TA: Panminerva Med Country: Italy |
Other Details:
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Languages: eng Pagination: 53-66 Citation Subset: IM |
Affiliation:
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Momentum Research Inc., 3100 Tower Boulevard, Durham, NC 27707, USA. gadcotter@momentum-research.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Cardiovascular Agents / therapeutic use* Evidence-Based Medicine Heart Failure / drug therapy* Humans |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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