Document Detail

The management of acute heart failure.
MedLine Citation:
PMID:  20228726     Owner:  NLM     Status:  MEDLINE    
Hospitalization for acute heart failure (AHF) is one of the burdensome aspects of 21st century medicine, leading to significant debilitating symptoms, high morbidity and mortality and consuming significant portion of the health care budget. Management of AHF is thought-provoking given the heterogeneity of the patient population, absence of a universally accepted definition, incomplete understanding of the pathophysiology and the beneficial and adverse effects of currently used therapies and lack of robust evidence-based guidelines. The article will discuss the clinical approach to the patients admitted with AHF, reviewing types of intervention (both approved and investigational) and will delineate their role and timing in specific AHF presentations. One of the challenges of AHF management is to effectively treat the subsets of patients with slow improvement or those with refractory AHF or early recurrence (worsening HF) during their initial admission. Unfortunately, the majority of these patients are at increased risk for subsequent complications and adverse outcomes. Therefore, considerable efforts in AHF management should be directed towards this population. Regretfully, to date no specific targeted therapy was proven beneficial for these patients, being one of the leading reasons for the lack of improvement in AHF outcomes over the last 30 years.
O Milo-Cotter; L Bettari; L Kleijn; S Bugatti; C Lombardi; M Rund; M Metra; A A Voors; G Cotter; E Kaluski; B D Weatherley
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Panminerva medica     Volume:  52     ISSN:  1827-1898     ISO Abbreviation:  Panminerva Med     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-07-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421110     Medline TA:  Panminerva Med     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  53-66     Citation Subset:  IM    
Momentum Research Inc., 3100 Tower Boulevard, Durham, NC 27707, USA.
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MeSH Terms
Acute Disease
Cardiovascular Agents / therapeutic use*
Evidence-Based Medicine
Heart Failure / drug therapy*
Reg. No./Substance:
0/Cardiovascular Agents

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