Document Detail

The mammalian brain rsec6/8 complex.
MedLine Citation:
PMID:  8982167     Owner:  NLM     Status:  MEDLINE    
rsec6 and rsec8 are two components of a 17S complex in mammalian brain that is homologous to the yeast 834 kDa Sec6/8/15 complex which is essential for exocytosis. Purification and partial amino acid sequencing of the mammalian rsec6/8 complex reveals that it is composed of eight novel proteins with a combined molecular weight of 743 kDa. The complex is broadly expressed in brain and displays a plasma membrane localization in nerve terminals. Membrane associated rsec6/8 complex coimmunoprecipitates with syntaxin, a plasma membrane protein critical for neurotransmission. These data suggest a role for the mammalian rsec6/8 complex in neurotransmitter release via interactions with the core vesicle docking and fusion apparatus.
S C Hsu; A E Ting; C D Hazuka; S Davanger; J W Kenny; Y Kee; R H Scheller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuron     Volume:  17     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-01-27     Completed Date:  1997-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1209-19     Citation Subset:  IM    
Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University Medical School, California 94305-5428, USA.
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MeSH Terms
Brain / metabolism*
Carrier Proteins*
Cells, Cultured
Hippocampus / cytology,  metabolism
Membrane Proteins / metabolism
Neurons / metabolism
Peptide Mapping
Precipitin Tests
Proteins / genetics,  isolation & purification,  metabolism*
Qa-SNARE Proteins
Subcellular Fractions / metabolism
Tissue Distribution
Reg. No./Substance:
0/Carrier Proteins; 0/Membrane Proteins; 0/Proteins; 0/Qa-SNARE Proteins; 0/Sec6l1 protein, rat; 0/Sec8l1 protein, rat

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