Document Detail

The mammalian UV response: mechanism of DNA damage induced gene expression.
MedLine Citation:
PMID:  7942283     Owner:  NLM     Status:  MEDLINE    
DNA damage inducing treatment of cultured mammalian cells triggers the activation of transcription factors and the prolongation of the half life of p53. As the earliest event detectable in the nucleus (5 min), AP-1 (c-Jun/c-Fos) is post-translationally modified. Triggering this early event and triggering subsequent transcription factor dependent processes requires extra-nuclear components of signal transduction such as Src, Ras, Raf-1 and MAP-2 kinase. Recent efforts have concentrated on examining whether DNA damage or other secondary effects of the damaging agent generate the signal then passed on to transcription factors. Further, it has been studied whether a pathway of reverse signalling exists that originates in the nucleus and reaches the cell surface. At the cell surface the UV induced signalling chain can be interrupted experimentally. Beyond this step DNA damage and signal transduction induced by phorbol esters and growth factors merge and reach the nuclear proteins through common components.
P Herrlich; C Sachsenmaier; A Radler-Pohl; S Gebel; C Blattner; H J Rahmsdorf
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Advances in enzyme regulation     Volume:  34     ISSN:  0065-2571     ISO Abbreviation:  Adv. Enzyme Regul.     Publication Date:  1994  
Date Detail:
Created Date:  1994-11-15     Completed Date:  1994-11-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0044263     Medline TA:  Adv Enzyme Regul     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  381-95     Citation Subset:  IM    
Kernforschungszentrum Karlsruhe, Institut für Genetik, Karlsruhe, Germany.
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MeSH Terms
DNA Damage / genetics*
Gene Expression Regulation / radiation effects*
Signal Transduction*
Transcription, Genetic / radiation effects
Ultraviolet Rays / adverse effects*
X-Rays / adverse effects

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