Document Detail

The mammalian Jun proteins: redundancy and specificity.
MedLine Citation:
PMID:  11402334     Owner:  NLM     Status:  MEDLINE    
The AP-1 transcription factor is composed of a mixture of homo- and hetero-dimers formed between Jun and Fos proteins. The different Jun and Fos family members vary significantly in their relative abundance and their interactions with additional proteins generating a complex network of transcriptional regulators. Thus, the functional activity of AP-1 in any given cell depends on the relative amount of specific Jun/Fos proteins which are expressed, as well as other potential interacting proteins. This diversity of AP-1 components has complicated our understanding of AP-1 function and resulted in a paucity of information about the precise role of individual AP-1 members in distinct cellular processes. We shall discuss recent studies which suggest that different Jun and Fos family members may have both opposite and overlapping functions in cellular proliferation and cell fate.
F Mechta-Grigoriou; D Gerald; M Yaniv
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Oncogene     Volume:  20     ISSN:  0950-9232     ISO Abbreviation:  Oncogene     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-06-12     Completed Date:  2001-07-05     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  England    
Other Details:
Languages:  eng     Pagination:  2378-89     Citation Subset:  IM    
Unité des virus oncogenes, CNRS URA 1644, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France.
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MeSH Terms
Amino Acid Sequence
Cell Cycle
Cell Transformation, Neoplastic
Molecular Sequence Data
Proto-Oncogene Proteins c-jun / genetics,  physiology*
Proto-Oncogene Proteins p21(ras) / physiology
Sequence Homology, Amino Acid
Signal Transduction
Transcription Factor AP-1 / physiology
Reg. No./Substance:
0/Proto-Oncogene Proteins c-jun; 0/Transcription Factor AP-1; EC Proteins p21(ras)

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