Document Detail


A malignant peripheral nerve-sheath tumour responding to chemotherapy.
MedLine Citation:
PMID:  14765877     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A malignant peripheral nerve-sheath tumour developed in the right S1 nerve root in a man aged 30 causing back pain and sciatica. CT and MRI revealed a destructive tumour of the sacrum invading the retroperitoneal space. The tumour was not resectable with an adequate margin. Chemotherapy, consisting of high-dose ifosfamide followed by a combination of vincristine, doxorubicin and cyclophosphamide, was given with success. Malignant peripheral nerve-sheath tumours are thought to respond weakly to chemotherapy, but the response in our patient was complete.
Authors:
F Masui; R Yokoyama; S Soshi; Y Beppu; K Asanuma; K Fujii
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of bone and joint surgery. British volume     Volume:  86     ISSN:  0301-620X     ISO Abbreviation:  J Bone Joint Surg Br     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-02-09     Completed Date:  2004-02-24     Revised Date:  2010-11-10    
Medline Journal Info:
Nlm Unique ID:  0375355     Medline TA:  J Bone Joint Surg Br     Country:  England    
Other Details:
Languages:  eng     Pagination:  113-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Orthopaedic Surgery, Jikei University School of Medicine, National Cancer Centre Hospital, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Back Pain / etiology
Cyclophosphamide / administration & dosage
Doxorubicin / administration & dosage
Humans
Ifosfamide / administration & dosage
Male
Nerve Sheath Neoplasms / complications,  drug therapy*
Sciatica / etiology
Vincristine / administration & dosage
Chemical
Reg. No./Substance:
23214-92-8/Doxorubicin; 3778-73-2/Ifosfamide; 50-18-0/Cyclophosphamide; 57-22-7/Vincristine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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