Document Detail

The malian medicinal plant Trichilia emetica; studies on polysaccharides with complement fixing ability.
MedLine Citation:
PMID:  12648827     Owner:  NLM     Status:  MEDLINE    
Trichilia emetica is a tree or bush that has many different traditional uses in Mali, amongst others the leaves have been used as a woundhealing remedy. As polysaccharides have been isolated from other plants that have a long tradition as woundhealing remedies, it was of interest to study the polysaccharides of T. emetica as well. The polysaccharides were extracted at 50 and 100 degrees C, and the polymeric material was separated into neutral and acidic polymers by anion exchange chromatography. The complement fixation ability of the different fractions was determined. The Acidic fraction 4 of the 100 degrees C extract was the most active, but most of the other fractions were also quite active. Structural studies showed that the most active fraction was a pectin of the rhamnogalacturonan type 1 with side chains of the arabinogalactan type II. Removal of terminal arabinofuranosides lead to a drop of the activity indicating that this structural unit may be involved in the bioactive site of the molecule.
Drissa Diallo; Berit Smestad Paulsen; Torun H A Liljebäck; Terje E Michaelsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  84     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-03-21     Completed Date:  2003-04-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  279-87     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Ireland Ltd.
Department of Traditional Medicine, BP 1746, Bamako, Mali.
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MeSH Terms
Complement Fixation Tests*
Complement System Proteins / drug effects
Erythrocytes / immunology
Meliaceae / chemistry*
Molecular Weight
Monosaccharides / chemistry
Plant Leaves / chemistry
Polysaccharides / chemistry,  pharmacology*
Sheep / immunology
Reg. No./Substance:
0/Monosaccharides; 0/Polysaccharides; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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