Document Detail


The male bias in the number of Purkinje cells and the size of the murine cerebellum may require Müllerian Inhibiting Substance / anti-Müllerian hormone.
MedLine Citation:
PMID:  21732997     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
There is a male bias in the size of the cerebellum, with males on average having more Purkinje cells than females. The critical periods in cerebellum development occur when the immature testes secrete Müllerian inhibiting Substance (MIS, synonym anti-Müllerian hormone) but only trace levels of testosterone. This suggests that the male bias in the cerebellum is generated by a different mechanism to the testosterone-sensitive reproductive nuclei. Consistent with this, we report here that Purkinje cells and other cerebella neurones express receptors for MIS, and that MIS(-/-) male mice have female-like numbers of Purkinje cells and a female-like size to other parts of their cerebellum. The size of the cell bodies of Purkinje cells was also dimorphic, but only a minority of this was due to MIS. This suggests that MIS induces the initial male bias in the cerebellum, which is then refined by pubescent testosterone and/or other sex-specific factors.
Authors:
Walter Wittmann; Ian S McLennan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-6
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  -     ISSN:  1365-2826     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Journal of Neuroendocrinology © 2011 Blackwell Publishing.
Affiliation:
Department of Anatomy and Structural Biology, Brain Health Research Centre, University of Otago, PO Box 913, Dunedin, New Zealand Current address, Umeå Center for Molecular Medicine, Umeå University, Sweden.
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