Document Detail

A major susceptibility locus for atopic dermatitis maps to chromosome 3q21.
MedLine Citation:
PMID:  11101848     Owner:  NLM     Status:  MEDLINE    
Atopic dermatitis (eczema) is a chronic inflammatory skin disease with onset mainly in early childhood It is commonly the initial clinical manifestation of allergic disease, often preceding the onset of respiratory allergies. Along with asthma and allergic rhinitis, atopic dermatitis is an important manifestation of atopy that is characterized by the formation of allergy antibodies (IgE) to environmental allergens. In the developed countries, the prevalence of atopic dermatitis is approximately 15%, with a steady increase over the past decades. Genetic and environmental factors interact to determine disease susceptibility and expression, and twin studies indicate that the genetic contribution is substantial. To identify susceptibility loci for atopic dermatitis, we ascertained 199 families with at least two affected siblings based on established diagnostic criteria. A genome-wide linkage study revealed highly significant evidence for linkage on chromosome 3q21 (Zall=4.31, P= 8.42 10(-6)). Moreover, this locus provided significant evidence for linkage of allergic sensitization under the assumption of paternal imprinting (hlod=3.71,alpha=44%), further supporting the presence of an atopy gene in this region. Our findings indicate that distinct genetic factors contribute to susceptibility to atopic dermatitis and that the study of this disease opens new avenues to dissect the genetics of atopy.
Y A Lee; U Wahn; R Kehrt; L Tarani; L Businco; D Gustafsson; F Andersson; A P Oranje; A Wolkertstorfer; A v Berg; U Hoffmann; W Küster; T Wienker; F Rüschendorf; A Reis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature genetics     Volume:  26     ISSN:  1061-4036     ISO Abbreviation:  Nat. Genet.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-15     Completed Date:  2001-01-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9216904     Medline TA:  Nat Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  470-3     Citation Subset:  IM    
Gene Mapping Centre, Max-Delbrück-Centre (MDC) for Molecular Medicine, Berlin, Germany.
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MeSH Terms
Child, Preschool
Chromosome Mapping
Chromosomes, Human, Pair 3 / genetics*
DNA / genetics
Dermatitis, Atopic / genetics*
Genetic Markers
Genomic Imprinting
Linkage (Genetics)
Nuclear Family
Reg. No./Substance:
0/Genetic Markers; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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