Document Detail

A major role of macrophage activation by interferon-gamma during mouse hepatitis virus type 3 infection. II. Age-dependent resistance.
MedLine Citation:
PMID:  2177034     Owner:  NLM     Status:  MEDLINE    
In contrast to adult mice, young A/J mice, developed an acute hepatitis following infection with Mouse Hepatitis virus type 3. 100% of the young animals died 4 to 5 days after the infection and high levels of virus were found in the liver and peritoneal exudate. Very low levels of IFN-gamma were found in the serum and peritoneal exudate of infected young mice. This was in contrast to the levels observed in adult mice. Spleen cells and macrophage cultures from young A/J mice, again in contrast to adult A/J mice, were shown to be unable to synthesize IFN-gamma and IFN-alpha/beta respectively. Macrophages from either young or adult A/J mice were able to be activated with exogenous recombinant IFN-gamma or IFN-alpha/beta, enabling both sets of cells to restrict MHV3 replication. The results indicate that the ability of the immune system to synthesize IFN-gamma and IFN-alpha/beta may play a major role in the age-dependent resistance of A/J mice to MHV3.
M A Lucchiari; C A Pereira
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunobiology     Volume:  181     ISSN:  0171-2985     ISO Abbreviation:  Immunobiology     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1991-02-28     Completed Date:  1991-02-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8002742     Medline TA:  Immunobiology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  31-9     Citation Subset:  IM    
Instituto Butantan, Laboratorio de Imunologia Viral, São Paulo, Brasil.
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MeSH Terms
Age Factors
Disease Susceptibility
Gene Expression Regulation
Hepatitis, Viral, Animal / immunology*
Interferon Type I / biosynthesis
Interferon-gamma / biosynthesis,  physiology*
Macrophage Activation*
Macrophages / metabolism
Mice, Inbred A
Murine hepatitis virus* / physiology
Spleen / metabolism
Virus Replication
Reg. No./Substance:
0/Interferon Type I; 82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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