| A major outbreak of hantavirus infection in Belgium in 1995 and 1996. | |
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MedLine Citation:
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PMID: 10459649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Haemorrhagic fever with renal syndrome (HFRS) is a human disease characterized by flu-like symptoms, renal dysfunction, and in severe cases, haemorrhagic manifestations. The causative agents of HFRS are Hantaan (HTN), Seoul (SEO), Puumala (PUU) and Dobrava (DOB) hantaviruses. Hantavirus infections are of increasing importance in Europe. Outbreaks occur in Belgium with a 3- to 4-year interval with an increasing number of cases. We describe the largest outbreak so far in Belgium with 217 serologically and clinically confirmed cases in the period between October 1995 and December 1996. We demonstrated that the use of viral antigen derived from a local PUU-strain was able to detect significantly more sera positive for IgM in an immunofluorescence assay. Furthermore, although in some cases SEO, HTN and DOB antibody-reactivities were detected by ELISA, only PUU infections could be confirmed by neutralization test. The presence of an unknown hantavirus serotype circulating in Belgium should be considered. |
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Authors:
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P Heyman; T Vervoort; P Colson; Y K Chu; T Avsic-Zupanc; A Lundkvist |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Epidemiology and infection Volume: 122 ISSN: 0950-2688 ISO Abbreviation: Epidemiol. Infect. Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-09-07 Completed Date: 1999-09-07 Revised Date: 2010-03-03 |
Medline Journal Info:
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Nlm Unique ID: 8703737 Medline TA: Epidemiol Infect Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 447-53 Citation Subset: IM |
Affiliation:
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Research Laboratory for Vector-borne Diseases, Queen Astrid Military Hospital, Brussels, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Distribution Aged Aged, 80 and over Antibodies, Viral / blood* Belgium / epidemiology Blotting, Western Child Child, Preschool Disease Outbreaks* Enzyme-Linked Immunosorbent Assay Female Fluorescent Antibody Technique Hantavirus / classification*, immunology, isolation & purification Hantavirus Infections / blood, epidemiology* Humans Male Middle Aged Seasons Seroepidemiologic Studies |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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